Research On Pharmaceutical And Preliminary Pharmacodynamics Of Sanjiezhitong Cataplasm

Sanjie pain Babu mainly by the re-building,diffusa,Prunella,ChuanWu,Araceae, borneol and other traditional Chinese medicine prepared from extracted with Endometriosis,pain swelling effect.For the pathogenesis of breast hyperplasia, prescription weight floor,diffusa Qingrejiedu,swelling pain stasis,liver and stomach and into the second after,the direct breast disease;Prunella can pass the means,the Sanjie pain; ice film Xinsan go channeling,swelling and relieve pain.Combination of Various drugs, topical disease location,make the drugs directly to patients,with detoxification Sanjie, active stasis,Tongluozhitong achievement.This re-established first floor, saponin, ursolic acid, hypaconitine HPLC determination method,the orthogonal experiment,active ingredients with anti-hyperplasia heavy floor saponin,ursolic acid,and has analgesic efficacy hypaconitine Extraction of the main targets,focusing on the concentration of ethanol and adding volume,refluxed time to three factors.The definitive extraction of prescription medicine to join the 8 times of 70% ethanol reflux twice 1 .5h.Optimized by uniform design,molding process Cataplasm,uniform design version 2.0 software with selected M12(125) Table arrangements experiments to Babu initial blank matrix viscosity,peel adhesion,adhesive strength of three factors invertigated Babu The shape of the blank matrix,obtained through the optimization of the matrix test formula:Kaolin:PVP:glycerol:water: NP-600:NP-700 the best ratio for: 0.1:0.2:1:3.5:0.2: 0.3.Uniform design verification teses show the accuracy and reliability. Sanjie pain Babu quality standard include re-floor herbs,Prunella vulgaris and TLC of Hedyotis diffusa;main ingredient efficacy Determination efficacy Determination Paridis saponins establishmeng; Babu basic routine examination,including with paste volume,adhesion,shaped nature. Test results showed that pain Babu Sanjie ointment containing the amount of adhesive, shaped to meet the requirements of;Sanjie pain Babu Babu saponin content of heavy floor, each piece not less than 2.0mg.The active ingredients of prescription hypaconitine and ursolic acid have been studied percutaneous absorption ,the results show:UA through the skin itself is diffcult to take in a certain penetration enhancers can be effective under the action of through the skin,and very low permeability.Hypaconitine itself through the skin,the ability to join after a certain penetration rate of transdermal enhancers faster.