Serum Ca19-9 And Cea Level Variance And Its Related Factors In Type 2 Diabetic Patients

Objective:To analyse the variance of serum CA19-9 and CEA level in type 2 diabetic patients and its related factors.Methods:397 hospitalized type 2 diabetic patients and 390 normal controls were included in the observation. Serum CA19-9 and CEA level were measured and its related factors were analysed.Results:1) Serum CA19-9 and CEA level were higher in diabetic patients than that in normal controls (P<0.01).2) Diabetic patients were divided into three groups according to HbAlc level:low-level group (<8.0%), medium-level group (8.0-10.0%) and high-level group (>10.0%). Both serum CA19-9 and CEA level were highest in high-level group, while lowest in low-level group, with significant difference (P<0.05 or P<0.01),suggesting an elevation of CA19-9 and CEA in disorder of glucose metabolism. The proportion of patients with CA19-9 level above reference range was the same in medium-level group and high-level group,both higher than that in low-level group (P=0.01); No significant difference was found in the proportion of patients with CEA level above reference range among three groups.3) Diabetic patients and normal controls were divided into three groups according to age: less-than-45-year-old group,46-to-60-year-old group and more-than-61-year-old group. No significant difference was observed in CA19-9 level among three groups of diabetic patients. CA19-9 level in the 46-to-60-year-old group of normal controls was higher than that in less-than-45-year-old group, but lower than that in more-than-61-year-old group (P<0.05). CEA level was highest in more-than-61-year-old group and lowest in less-than-45-year-old group of diabetic group (P<0.05), but no difference was found among three group of normal controls. The proportion of patients with CA19-9 or CEA level above reference range showed no difference among three groups of diabetic patients.4) Women patients with diabetes had higher CA19-9 level than men patients (P<0.001), but no difference was found in CEA level between women and men patients with diabetes. CA19-9 and CEA level in normal controls showed no difference between women and men. No difference was found between women and men diabetic patients in the proportion of patients with CA19-9 or CEA level above reference range.5) Multiple logistic regression analysis showed that HbA1c was an independent risk factor for CA19-9 elevation in diabetic patients (P<0.01); Age and HbA1c were independent risk factors for CEA elevation in diabetic patients (P<0.01 or P<0.05).Conclusion:Nonmalignant elevation of CA19-9 and CEA could be observed in diabetic population, which was positively related with HbA1c. Women patients with diabetes had higher CA19-9 level than men patients, while CEA level increased as well as age increased. Serum levels of tumor biomarkers should be follow up dynamically in diabetic patients, especially after the restoration of metabolic disorder.