| Objective: To explore the associations of serum sodium, potassium, calcium and albumin concentrations with severity of coronary artery disease (CAD).Methods: A retrospective study was conducted to analyze 358 patients in Wuhan Union Hospital in 2008. The patients were divided into 4 groups, acute myocardial infarction (AMI), old myocardial infarction (OMI), CAD without myocardial infarction (MI), and the normal control group. Gensini scoring system was utilized to evaluate the severity of CAD.Results: (1) There were 51 cases of AMI (14.2%), 56 cases of OMI (15.6%), 179 cases of CAD (without MI) (50.0%) and 72 cases of the control group (20.1%). The average Gensini scores among patients with CAD were significantly different (P=0.000). The average scores in patients with AMI [39 (27 to 72)] was the highest, in patients with OMI [36 (22 to 57)] was a little lower, and in patients with CAD (without MI) [28 (15 to 42)] was the lowest. The average concentrations of serum calcium [AMI: (2.13±0.29) mmol/L, OMI: (2.34±0.22) mmol/L, CAD without MI: (2.36±0.22) mmol/L] and albumin [AMI: (38.5±5.1) g/L, OMI: (41.3±3.9) g/L, CAD without MI: (41.6±3.6) g/L] in patients with 3 CAD groups were significantly lower than the control group [serum calcium: (2.42±0.15) mmol/L, albumin: (42.8±4.0) g/L] (all P<0.05), the average concentrations of serum calcium and albumin in patients with AMI were significantly lower than other CAD groups (all P<0.05), and the average concentrations of serum sodium and potassium in patients with AMI were also significantly lower than the other groups (except OMI group in serum potassium) (all P<0.05). (2) The negative correlations of serum calcium and albumin concentrations with Gensini score were significant in all patients, the spearman's r of serum calcium was -0.175 (P=0.003), and of serum albumin was -0.200 (P=0.001), but there were no significant associations of serum sodium and potassium concentrations with Gensini score (both P>0.05). Results of logistic regression indicated that hypocalcemia was a risk factor for CAD (OR=2.618, 95%CI 1.025-6.690, P=0.044) when adjusted for conventional risk factors.Conclusions: The lower levels of serum sodium, potassium, calcium and albumin concentrations may be caused by AMI, there are significant negative correlations of serum calcium and albumin concentrations with severity of CAD, and hypocalcemia may be an independent risk factor for CAD.Objective: To observe seasonal variation in plasma lipid and lipoprotein levels in patients with CAD in Hubei.Methods: Retrospective study of 364 patients with CAD in 2008 at Wuhan Union Hospital was conducted. The patients were divided into 4 groups (spring, n=96; summer, n=80; autumn, n=97 and winter, n=97), and the plasma lipid and lipoprotein levels were compared among each group.Results: The mean value of total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) showed significant seasonal variation (both P<0.05). TC in autumn and winter increased about 0.31-0.36 mmol/L compared to that in spring and summer, and HDL-C in autumn and winter both increased about 0.12-0.13 mmol/L compared to that in summer. There was also some change in low density lipoprotein cholesterol (LDL-C), LDL-C in winter increased about 0.16 mmol/L compared to that in spring and summer, but this change had not achieved statistical significance (P>0.05).Conclusions: There is significant seasonal variation in TC and HDL-C in patients with CAD in Hubei province. |
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