The Comparative Study Of Micro-inflammatory State And Nutritional Status Of Patients With Diabetic Nephropathy And Non-diabetic Nephropathy Peritoneal Dialysis

Background&Objective: Peritoneal dialysis(PD) as one of a renal replacement therapy provide a possibility for the patients with end stage renal disease(ESRD), it is popular by medical workers and patients with ESRD because of its advantages such as effectivity of clear the molecular substances, little effect on haemodynamics, protection of the residual renal function effectively, simple operation at home and so on. But the chronic complications of peritoneal dialysis are gradually highlighted with its wide range of applications, among them, the micro-inflammatory state and nutritional status are given more and more attention because they are closely related to the prognosis of patients with PD. It is reported that the risk of death of PD patients with diabetic nephropathy is higher than that of PD patients with non-diabetic nephropathy, so if there is a difference between these two kind of patients about the micro-inflammatory state and nutritional status, the reports are still rare recently.This study is about to test the level of inflammatory response indicators and the nutrition indicators of CAPD patients with detect diabetic nephropathy and non-diabetic nephropathy, comparing the differences, approaching the relationship between them, and order to provide a theoretical basis of intervention for DN peritoneal dialysis patients with micro-inflammatory state.Methods: Choose 30 PD patients with diabetic nephropathy and 43 PD patients with ion-diabetic nephropathy, all patients were excluded complications such as acute infection, cancer ,autoimmune diseases and so on and given peritoneal dialysis for more than three months. Test the inflammatory response indicators of all patients such as high-sensitivity C-reactive protein,interleukin-6 and nutrition indicators such as serum albumin (ALB), creatinine (SCR), blood urea nitrogen (BUN), total cholesterol (TC) and triglyceride (TG) compare the difference and approach the relationship of the two above-mentioned indicators of the patients.Results: 1,The level of serum hs-CRP and IL-6 of PD patients with diabetic nephropathy are higher that of PD patients with non-diabetic nephropathy, the difference has statistical significance (P <0.01). 2,The level of serum ALB,SCR and BUN of PD patients with diabetic nephropathy are lower that of PD patients with non-diabetic nephropathy, the difference has statistical significance (P <0.01); The level of serum TC are higher than that of PD patients non-diabetic nephropathy, the diffenrence has statistical significance (P <0.01), however, TG has not(P>0.05).3,The level of serum hs-CRP has a negative correlation with ALB (r=-0.663;P <0.01). positive correlation with TC(r=0.455;P <0.01), no correlation with SCR,BUN and TG(r=-0.119,r=-0.187,r=0.196;P>0.05). The level of serum IL-6 has a negative correlation with ALB,SCR(r=-0.364,r=-0.251;P <0.01). positive correlation with TC ( (r=0.388;P <0.01), no correlation with BUN and TG(r=-0.215,r=0.109;P>0.05).Conclusions: There is a more visible micro-inflammatory state and poor nutritional status of PD patients with diabetic nephropathy than that of PD patients with non-diabetic nephropathy, the negative correlation between them is obvious.