The Correlation Between Hla-a Allele And Anaphylactoid Purpura In Children Of Mongolia In Inner Mongolia

Objective To explore the association between HLA-A allele and Anaphylactoid Pur-pura(AP)in children of Mongolia in Inner Mongolia. We want to find correlated genes and study part of pathogenesis and the method of prevention and cure of AP.Method We a-dopted the method of case control and we selected 56 children AP as case group and health children 66 as control group in Mongolia,who had resided in Inner Mongolia three generations without consanguinity,history of mixed,marriages,other medical history,and family history of immunity,led into polymerase chain reaction sequence specific oligonucleotide probes(PCR-SSO)technique,analyzed the type of HLA-A allele.The compare of gene frenquency made with logistic regression after x2 or Fisher test. Result The gene frenquency of HLA-A*11 allele in case group(16.1%)compared to that of control group(9.1%),Wald of HLA-A* 11 gene was 3.954,P=0.047,the difference had statistical significance.B=0.844>0,OR =2.325>1,it helped development of the disease.whose 95% confident interval was 1-012-5.340,and which did not include 1,it was statistical significance,EF=0.342>0.Conclu-sion HLA-A*11 allele may be the haplotype susceptible gene of AP in children of Mon-golia in Inner Mongolia.