C-myc Gene, And Pcna Expression In The Cardia Of The Different Ethnic Groups In Xinjiang And Its Clinical Significance

Objective: To study the abnormal expression of C--myc and proliferating cell nuclear antigen (PCNA) in cardiac carcinoma tissues in the different ethnic. group in XinJiang and its clinicopathological significance. It may offer a useful data for this Cancer's prevention and treatment. Methods: The C-myc and PCNA protein ~n 91 cases of cardiac carcinoma tissues (Iiygur 31, karzak 30, Han 30) and 31 cases of non-Tumor tissues were examined by iminunohistochemical LSAB (Labllad Streptavidin-Biotin) technique.Results: (1) The positive frequency of C~myc and PCNA protein were 76.9%(70/91) and 97.8% (89,~9l) respectively. There was no statistic significance of C-myc and PCNA protein expression among the different ethnic groups in XinJiang (Th0.05) (2) The positive frequency of C-myc and PCNA protein were 10. O%(3/30) 13 32. 3% (10/31) respec-tively in non-tumor tissues of patients with cardiac carcinoma . The expression were of notably statistic difference between the cancer and non-tumor tissues (P(0.oi). (3) The overexpression of C-myc and PCNA protein were closely associated with histological grade, cancer invasive depth and lymph node metastasis situation.Conclusion: (1) The overExpression of C-myc and PCNA protein might play an importait role on cardiac carcinogenesis and cancer progression . (2) The expression of C-myc and PCNA could be identified as useful molecular markers for diagnosis and prognosis of cardiac carcinoma . (3) There was no significant difference of expression of C-myc and PCNA protein in tumor tissues among the different Ethnic patients in XinJiang.