| Objective To explore the changes and clinical significance of the plasmic Angiotensinâ…¡ (Angâ…¡) Neuropeptide Y (NPY) neurotensin (NT) and Intact Parathyroid Hormone (iPTH) in patients with chronic renal insufficiency . Methods The plasmic Angâ…¡,NPY and NT were measured by radioimmunoassay (RIA). The serum iPTH were measured by immunoradiometric assay (IRMA). All subjects were devided into four groups: 20 cases normal control group(group A),20 cases of chronic renal insufficiency compensated (group B),20 cases of azotemia (group C) and 20 cases of uremia (group D).Results With the severity of renal failure,the level of Angâ…¡was shown a ascending tendency according to the sequence. Groups C and D were higher than normal control group (P<0.001);The concentration of NPY (Groups B,C and D) were higher than group A (P<0.05); The level of NT was shown a decending tendency,group D were lower than group A (p<0.001); The iPTH (Group D) were significant higher than group A (P<0.001).In addition to,the negative correlation between Angâ…¡ or NPY or iPTH and Ccr ,the positive correlation between NT and Ccr,negative correlation between Angâ…¡ and NT were found .Conclusion The increased Angâ…¡,NPY iPTH and decreased NT play important roles in the further harm of kidney function and also provide theoretical bases for the preventions and treatments in chronic renal failure. |
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