Disinfection Suppository In The Treatment Of Cervical Human Papillomavirus Infection In Clinical Pharmacology Studies

Cervical Human Papillomatous Virus (HPV) infection is one of sexually transmitted disease which is going up year by year for the past few years. Especially in insidious symptom subclinical infection is generally exist. Now it has been ascertained that high risk human papillomatous virus (HPV) infection is the main factors in cervical carcinoma and lesion precancers. Cervical carcinoma disease incidence in our country is still account the first place in women' malignant tumours . And cervical carcinoma is the main cause of women' death. However there are still no specific remedy to treat cervical HPV infection at present. Accordingly it is of great importance to develop Chinese medicine to find external application with good effect and little side effect.QingDuShuan has been studied by Prof. Jin Zhe for many years as wellas gained well curative effect. On the base of about ten years' research, it is clear that QingDuShuan can block virus replication , lessen inflammatory reaction in cervix partly, sublime immune function and counter multiplication. As well as it can treat cervical intraepithelial neoplasia(CIN). This study has systematically summaried research advancement about cervical human papillomatous virus(HPV) infection on diagnostic technique, carcinogenesis mechanisms and treatment in recent years.It applies hybridcapturell(HC II) technique which is developed by American Digene corporation, which is the only one approved by Bureau of Food and Drug Administration (FDA), which is a kind of new technique used by unradioactive assay in clinic. The study use AnDaFen (interferon, ITF) compared with QingDuShuan to identify the action in cervix HPV virus loading dose and carried out statistics in clinical symptom integral calculus at equal pace in cervix HPV subclinical infection. The resultsmanifested AnDaFen and QingDuShuan can effectively cut down the ratios of HC- II HPVRlu/co ( virus loading dose ) altogether. Two sets own controlled in prior treatment and post-treatment equal have statistical significance (P<0. 05) . Compared between two sets without significant difference (P>0. 05). It also acquired that two drugs have obviously effect in clinical symptom and physical sign (P<0. 01) . The results of study hint that QingDuShuan has sure curative effect on subclinical cervix HPV infection .Pharmacology empirical study of QingDuShuan also be carried out in this study. According to the result of each group Cobaya in allergizing touching experiment and suscitation touching experiment—none occurrence of eryth and dropsy, it certificates that QingDuShuan has no allergization . It is safe in external use. The result of each group Cobaya in anti-inflammatory experiment definitely certificates that QingDuShuan has conspicuous anti-inflammatory effect. It provides reliable evidence in QingDuShuan clinic using on treating cervix HPV infection.