Experimental Study, Estrogen-like Effects Of Drugs Commonly Used In Treatment Of Menopausal Syndrome

Menopausal syndrome is owing to the decay of the ovaries fuctions, the estrogen level obviously decends, which causes the functional disorders of blood vessel , nerve and endocrine system, and which induces the functional uterine bleeding, hectic fever, diaphoresis, the atrophy of cunnus and vagina, osteoporosis and neurovegetative syndromes. With the aging of population structure in china, the age of onset shifts to an earlier time and the disease incidence is ascendant, which severely influence the health and quality of life during perimenopausal period and postmenopause occupying one third lifetime.Menopausal syndrome gives a direct impact on the proper functioning and living due to the high incidence , for the moment the dominating therapy is hormone replacement therapy(HRT). Estrogen is a steroid hormone with extensive contribution, which plays an important roles not only in maintaining the reproductive function and the secondary sex characters of the female animals but also in so-classical target tissues, such as the gential tract, mammary gland, bone, cardiovascular system. ERT can lessen the menopausal syndrome, prevent and cure osteoporosis. However, the long-term ERT could increase the onset risk of endometrial cancer . The HRT of the association between progestogen and estrogen grows downwards the risk , but the onset risk of breast cancer, cardiovascular and cerebrovascular disease increase. Although the estrogen gets pretty good curative effect in ameliorating the menopausal syndrome, the clinical sideeffect perplex the women.Phytoestrogens are naturally occurring plant chemicals that can produce an estrogen-like effect in the body, which are capable of binding estrogen receptors and have two-phase regulations. They suppress significantly growth of tumors dependent on estrogens, and also reduce menopausal symptoms. As a natural alternative to HRT , the phytoestrogen gains more and more attention. The source of Chinese medical materials in China is rich, but the study on phytoestrogen is rare. So to screen phytoestrogen from Chinese herbs is practicable and feasible way.The ingredients of each traditional Chinese medicine are complicated and the phytoestrogen activities are different, so we can select Chinese medical materials which are frequently used in clinic according to the theory of traditional Chinese medicine and some phytoestrogen description in the documents,...