The Rock Dracocephalum Chemical Composition Of Study

Dracocephalum rupestre Hance. is a plant widely distributed in Liaoning, Shanxi, Neimeng, Hebei, Qinghai Province, which belongs to Labiatae family. It is also called Mao Jian Cao, Mao Jian, Mao Jian Cha. In order to further ulilize the resource, the studies on the constituents of Dracocephalum rupestre Hance. were carried out.In the first part of this dissertation, the chemical study of Dracocephalum rupestre Hance was carried out. 9 compounds were isolated from the aerial part of Dracocephalum rupestre Hance. by chromatography with silica gel, polyamide and Sephadex LH-20. The structures were elucidated by chemical reactions, IR, MS, ¹H-NMR, ¹³C-NMR and by comparing with some authentic samples or standard spectral data of the known compounds reported in the literatures. These structures were proposed as following:(I) 3,13-dihydroxy-ursan-28,13-olide, (II) luteolin, (III) eriodictyol-7-O-β-D-glucoside, (IV) oleanolic acid, (V) betulinic acid, (VI) p-sitosterol, (VII) 3-daucosterol, (VIII) stearic acid, (IX) n-octadecyl octadecate. Compounds I, IV, VIII and IX were obtained from Dracocephalum rupestre Hance. for the first time.In the second part, the chemical and bioactivities of Dracocephalum plants were surveyed. Dracocephalum is a large genus of more than 60 species in the world, distributed all over Asia. There are 32 species in our country, which are distributed in the northeast, northwest, and southwest. The main chemical constituents of Dracocephalum plants are volatile oils, flavonoids, steroids, triterpenoids, organic acid and esters, respectively. It was reported that Dracocephalum plants had the function of antibacterial, suppressing asthma and relieving cough, some of which were found to prevent cardiovascular disease and to protect some organ and tissue of animals in the hypoxia environment.