Chip Implanted Closed-loop Blood Pressure Control System Of Normal And Hypertensive Rats Buck Effect And Hypotensive Mechanism Of Acute Experimental Studies

Hypertension is one of the most common cardiovascular diseases. The incidence of the disease was as high as 18.8% and increased very quickly. However, the mechanism of hypertension is not completely known. Medication is a therapy of non-physiologic regulation on blood pressure, and usually produces many side effects. Recently, chip-implanting method has been a focus of non-medication therapies to cure many diseases. However, the chip system used to control blood pressure has not been reported as yet. In order to find a new physiological way to cure hypertension, the mechanism of hypertension was clarified further in this paper and a special chip system to modulate blood pressure was designed and implanted in animals in the acute experiment. The results from normotensive and hypertensive rats showed that the chip system was very effective to control blood pressure.Twenty two male SHR, sixteen 2K1C rats and twenty-eight male Wistar rats weighing between 250 g and 300 g were used in the study. The chip system was primarily composed of a microprocessor, A/D convertor, built-in bridge amplifier, and the connecting interface of transducer and stimulating electrodes. The basic working principle of the chip system was simply expressed as the linear relationship between the input mean arterial pressure (MAP) and output frequency of stimulus. The increased stimulation of aortic depressor nerve (ADN) resulted in an enhanced depressor reflex followed by a...