Diabetic Peripheral Neuropathy And Of Crp, Pai-1 Factor-related Nature

In the thesis: C-reactive protein (CRP) in serum and plasminogen activator inhibitor-1 (PAI-1) are investigated in normal rats and diabetes mellitus rats with and without peripheral neuropathy. The relationships between these two factors and diabet ic peripheral neuropathy and the effect of these two factors to the development of diabetic peripheral neuropathy have been discussed.Methods: One hundred rats with type-2 diabetes mellitus caused by the intra-peritoneally every two day injection of low grade inflammation alloxan tetrabydate have been divided to two groups, i. e. normal control and model, after raising by one month. Then those rats whose value of fasting blood glocuse lies between 16.7 and 25 are chosen. Three months later, these selected rats with diabetes mellitus form two types, that is with and without peripheral neuropathy due to the speed of nerve conduct. Finally, CRP and PAI-1 of these different groups are measured.Results: The contents of CRP and PAI-1 in rat groups with diabetes mellitus both increase by comparison with normal rats. For model of diabetes mellitus rat there is a big difference of CRP increase between diabetes mellitus rat with peripheral neuropathy and without peripheral neuropathy. However, PAI-1 are almost same. Conclusion:1.CRP play an important role for the development of diabetic peripheral neuropathy.2. There will possibly be inflammation due to the correspondence between CRP and diabetic peripheral neuropathy.3. PAI-1 is no relation with DPN according to the evidence prove.