Extremely Low Frequency Electromagnetic Fields On The Blood - Brain Barrier, The Role Of Morphine Dependent Rats Withdrawal State Prefrontal Ventral D <sub> 2 </ Sub> Receptor Changes

Objective :To study effects of extremely low frequency electromagnetic fields (ELFEF)on theblood-brain barrier (BBB) through the comparison of epileptic effects of penicillin on ELFEFtreated rats and normal Rats.Methods: Twenty-four male Sprague-Dawley rats were divided equally into four groupsrandomly, groupA₁(normal BBB),groupA2(damaged BBB) , groupB₁(ELFEF treatment for 1h)and groupB2(ELFEF treatment for 24h). All groups were injected intraperitoneally penicillin by6000,000 units/kg.To observe epilepsy induced by penicillin in rats and record the Racine'sdegree of seizure,then,all data were dealt with by statistical method. To compare the Racine'sdegree of seizure of each group.Results: 1 .There is statistically significant difference in epilepsy induced by penicillin betweengroupAi and groupA2(P<0.01) ,while GroupA2 is higher than groupAi on the Racine's degree ofseizure.2.There is no statistically significant difference in epilepsy induced by penicillin betweengroupAi and either subgroupB(P>0.05).3. There is statistically significant difference in epilepsy induced by penicillin between groupA₂ and either subgroupB (P<0.01) .GroupA2 is higher than either subgroupB on the Racine's degree of seizure.4. There is no statistically significant difference in epilepsy induced by penicillin between groupB₁ and groupB₂(P>0.05).Conclusion: 1. BBB of rats can't be damaged by ELFEF (20Hz, 14mT) within 24h infer that there is no effects on BBB after a short time ELFEF treatment.