| Objective:Through the clinical trial research, the observation of electro-acupuncture (EA) JIAJI points and Aconite cake-separated temperate moxibustion can reduce the poison and increase the efficiency of salicylazosulfapyridine (SASP) ,and it treats the ankylosing spondylitisis's mechanism .Further explores the cooperation of Chinese and Western medicine to treat the ankylosing spondylitisis's security effective scheme.Methods:1 clinical material: All ankylosing spondylitisis(AS) patient originates from the Wuhan Chinese medicine hospital Rheumatism Branch special clinic and in-patient department. From May, 2007 to February, 2008, altogether admits AS patient 60 examples, uses stochastically,the masculine medicine parallel comparison design method, divides into the experimental group and the control group, experiments the group 30 examples, control group 30 examples.2 methods of treatment:â‘ Control group (SASP group): 30 examples, give the salicylazosulfapyridine oral administration, first week each time 0.25g, the second week is 0.5g, the third week was 0.75g finishes until the treatment course, daily 3 times, altogether 12 weeks.â‘¡Experimental group (SASP+acupuncture group): 30 examples, above the control group treats gives the electro-acupuncture again and Aconite cake-separated temperate moxibustion, treats 12 weeks later observes the curative effect.â‘¢When the few patient joint ache is hard to endure, uses judgment the temporary oral administration loxoprofen, each time 60mg, daily three times, does not make the conventional treatment (symptom to reduce, then stops medicine). In addition, does not use the medicine that treats this sickness related other traditional Chinese medicines and the western medicine.3 observation targets: Secure target including common physical examination, heart, lung, liver, kidney function and blood, urine, stool routine and so on ;The curative effect target includesâ‘ Cardinal symptoms: The waist shinbone ache, the back ache, the waist keel activity is limited, the lumbodorsal region early morning to be stiff, the joint ache, the joint swelling, the waist knee worn out and aching sleepy heavy, gives off heat.â‘¡Main symptom: Visual Analogue Scale, the pillow wall is apart from, refers to is apart from, the Schober experiment, the chest gallery activity, " 4 " the character experiment, the pelvis extrusion, the separation experiment.â‘¢Laboratory target: HLA - B27,ESR,CRP,IgA,ALP.â‘£Radioactivity inspection: Two-sided sacroiliac joint X normal position piece.4 statistical methods: Uses the SPSS13.0 software package to carry on the data statistical analysis, in the measurement dataset compares uses the pair mean value T-test, the group compares uses two independent sample mean value T-test; The ranked data examines with Ridit, the grouped data uses the chi-square test, P<0.05 was considered examines the difference has statistics significance.Results:the two group of altogether 60 example patients complete the treatment course, the compliance are good, has not appeared falls off, the rejection case.1 After two group of patients treat, the total curative effect passes through the analysis,experimental group total effectiveness 93.33%, will control obviously (near future to control and appearance) rate 66.67%; Control group total effectiveness 76.67%, control obviously leads 40%, two group of total curative effect comparisons have statistics significance (P<0.05).2 After two group of patients treat, the Chinese medicine card period of five days curative effect passes through the analysis, the experimental group is always effective is 86.67%, controls obviously leads 56.67%; Control group total effectiveness 76.67%, control obviously leads 22.22%, two group of card period of five days curative effect comparison has statistics significance (P<0.05).3 Around the clinical symptoms curative effect aspect, the experimental group treats is quite even has the significance difference (P<0.05); The control group compares the non-significance difference besides the circumference joint swelling item of integral valve treatment around (P>0.05), other each item of host, around the time sickness integral treatment is quite even has the significance difference (P<0.05); After the treatment, the group the comparison, has the significance difference (P<0.05). 4 Around the main symptom comparison, two group of patient's Visual Analogue Scale, the pillow wall is apart from, refers to is apart from, the Schober experiment and the chest gallery activity aspect, the experimental group treats the comparison to have the significance difference (P<0.05), around the control group treats compares also has the significance difference (P<0.05), and treats the latter two group of patient group the comparison to have the significance difference (P<0.05); "4" the character experiment, the pelvis extrusion, the separation experiment aspect, treats the latter two group of patient group the comparison to have the significance difference (P<0.05).5 Around the laboratory target aspect, by ESR, CRP, IgA, ALP takes the observation target, the experimental group treats ESR, CRP, the IgA value to have significance difference (P<0.05), ALP to have the unusual significance difference (P<0.01); Around the control group treats ESR, CRP, IgA, the ALP value to have the significance difference (P<0.05); After the treatment, the group compares ESR, CRP, IgA also to have significance difference (P<0.05), ALP to have the unusual significance difference (P<0.01).6 The sacroiliac joint X normal position piece aspect, treats the latter two group of sacroiliac joint X normal position piece change not obvious difference (P>0.05).7 After the treatment, the untoward effect aspect, the experimental group 5 example patients present the temporary mild digestive tract to be ill; The control group 2 example patients present the moderate untoward effect, 12 example patients present the mild digestive tract to be ill. Two group of untoward effect situation comparison has the significance difference (P<0.05).Conclusion:This clinical trial research indicated, the electro-acupuncture (EA) JIAJI points and Aconite cake-separated temperate moxibustion union salicylazosulfapyridine (SASP) the group to treat ankylosing spondylitisis curative effect to surpass salicylazosulfapyridine group, And the side effect formation rate reduces obviously, has the very good synergism, firmly for this sickness treatment safe effective method. Are worth the further deep research regarding the acupunture therapy this sickness's mechanism and the forward curative effect. |
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