| Objective:Observe the Dan Shen Yin He Xiao Xian Xiong Tang to coronary heart disease anginapectoris clinical curative effect,And through clinical research,discussing the Dan Shen Yin He Xiao Xian Xiong Tang to coronary heart disease angina pectoris patient homocysteic acid,high sensitive C-reactive protein,blood rheology,blood fats, and so on intimal media thickness of senile carotid influence.Inqui(?)y into its curative effect mechanism too.Method:1.Clinical data:80 the examples extend anginapectoris patient',all come from the hospital of Xiangfan affiliated to the Hubei College of Traditional Chinese Medicine.Conforms to "Practical Internal medicine" thediagnosis standard,the card is theTan Yu Bi Zu Xing.Press to seek medical advice the sequence is divided into two random,then cure the set,matched control.Before they accept the curing medicine, the objects should have the investigate score of Chinese medicine symptom,the medical examine.Two sex,age,course of illnesses,angina pectoris strict specific weight graduation and classify of the state of anilless are learn by covariance to handle to have no obvious difference(P＞0.05).Have can compare.2.The medical usage:Matched control 40 example,Gives the western medicine for the expansion coronary artery crown and the improvement cardicmuscle lacks the blood,Xiao Xin Tong pian 10mg,Every day 3,A Si Pi Lin Chang Rong pian 75mg, Every day 1,and the convention the treatmen to fall the blood pressure,ACEI and the persistent effect calcium oppresses the anti-medicinalpreparation(CCB),when necessity jointly oppresses the anti-medicinal preparation using the acceptor, mergeing the diabetes and the high lipemia patient simultaneously give the treatment of falling the sugar and falling the fat.Cure the set 40 example,in the comparison group foundation stopping using the western medicine and falls the fat medicine of expanding the crown and the improvement cardic muscle lacks of the blood,only gives medicine of falling presses and falling the sugar,and takes orally the Dan Shen Yin He Xiao Xian Xiong Tang,1 medicinal preparation,the water fries 2 times every day,will divide sooner or later 2 time to take.Two groups stop using the medicine which othertreatment books gets sick in the treatment period,the treatment time take 4 weeks as 1 treatment course,two groups of sickness average per person treat 2 treatment courses.3.The toxicity and the side-effect:Two sufferer differences carry on the Blood-routine,Urine-routine,Stool-routine,liver function and the kidney function examination in front and back in the treatment,to make sure the Dan Shen Yin He Xiao Xian Xiong Tang whether had any poisonous or side-effects.4.The curative effective observation:Observe two patient treatments in front and back the symptom,body advertise for,the certificate wait of improvement,homocysteic acid,high sensitive C-reactive protein,blood fats,blood rhedogy and so on intimal media thickness improves the circumstance,and make to statistics to learn the processing,comparing its curative effect.5.The Stat.method:Calculate the t-text that the data adoption becomes a data, the data use((?)±s)to mean,the count materials are examined with X~2,the grade data with the Radit analysis.Results:1.The side-effect and the toxicity:Cure the set and matched controls during the period of clinical studies,all do not appear to respond obviously side-effect and toxicity function.The three greatest normal regulationses,blood sugur,electrolyte the liver and the kidney functions are cured and do not appear the related abnormality change in front and back.2.Clinical curative effect comparison:The symptoms and signs of the patinents of the two groups after the treatment are more better than those before the treatment.Compared between the two groups,the treatment group clinical shows results 24examples,effective 13 examples,invalid 3 examples,total effectiveness 92.5%;The matched control clinical shows results 15 examples,effective 18 examples,invalid 7 examples,total effectiveness 82.5%,after statistics analysis,the total effectiveness has significant difference beween the cure the set and matched control(P＜0.05).Around two groups treat the group the comparison,before the treatmentthe not obvious difference,after the treatment the treatment group homocysteic acid level to drop obviously has significant difference compared with the matched control group(P＜0.05).After two group of patients treat,blood plasma high sensitive C-reactive protein equally obviously to reduce,have significant difference (P＜0.05);Around two groups treat the group the comparison,before the treatmentthe not obvious difference,after the treatment the treatment group C-reactive protein level to drop obviously has significant difference compared with the matched control group(P＜0.05)There are significant difference beween two groups in the blood fats-TG,TC,LDL-C,both have the distinct improvement,the HDL-C are not obvious difference(P＞0.05).There are significant difference beween two groups in the blood rheology each target,both have the distinct improvement.There are significant difference around two groups in the intimal media thickness level (P＜0.05),and also the treatment group more better than the comparison group in the intimal media thickness level(P＜0.05).Above the result indicated the Dan Shen Yin He Xiao Xian Xiong Tang can improvethe angina pectoris patient clinical symptom, the body drafts,may effectively improve the patient quality of life,reduce the patient pain.3.The Chinese medicine certificate waits the curative effect improvement to compare:Two treatment inside set in front and back the Chinese medicine symptom curative effect compare,was analyze by Radit,the P＜0.05,express two medicine to all have the very obviously improvement to the Chinese medicine symptom.Cure the set obviously high in matched control.ALL above express the Dan Shen Yin He Xiao Xian Xiong Tang have the obvious improvement of angina pectoris with huo tan tong luo and huo xue hua yu.Conclusion:1.The Dan Shen Yin He Xiao Xian Xiong Tang has the accurate curative effect to the coronary disease angina pectoris patient,may alleviate the coronary disease angina pectoris clinical symptom,also has not had the the toxicity and side-effect.2.The Dan Shen Yin He Xiao Xian Xiong Tang may reduce homocysteic acid, high sensitive C-reactive protein,intimal media thickness level of coronary disease angina pectoris patient.3.The Dan Shen Yin He Xiao Xian Xiong Tang may reduce blood fats and blood rheology level of the coronary disease angina pectoris patient. |
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