Viral Hepatitis Clinical Epidemiological Studies

PartⅠ:Analyze the etiology of viral hepatitisObjective:Analyze the etiology of viral hepatitis based on serial serum detection.Methods:The medical record,serial sera and feces of hospitalized acute viral hepatitis in this hospital were collected.Serum hepatitis markers and hepatitis E viral nucleic acid in patients' feces were detected respectively by ELISA and / or RT-nPCR.Results:It most easily to misdiagnosis between acute hepatitis B and chronic hepatitis B acute episode in clinic.Conclusions:The diagnosis to viral hepatitis may be more exact in clinic by serial serum test.PartⅡ:Comparison of clinical features among different type of acute hepatitisObjective:To compare the differences in clinical features among different type of acute hepatitis.Methods:The medical records of the acute hepatitis cases in hospital were collected to analyze the epidemiology and clinical features of different type of acute hepatitis.Results:In comparison to hepatitis A,and hepatitis B,patients with hepatitis E were older(39.70±15.86,39.84±11.69 vs 49.00±14.52 years,P＜0.01),and compare to other hepatitis,patients with hepatitis A were most likely to have a temperature(P＜0.01).In laboratory data,hepatitis B patients had highest serum levels of lanine aminotransferase(1391.47±566.17U/L),and aspartate aminotransferase(832.43±786.52 U/L),and most likely abnormal in albumin(100%),hepatitis E patients had highest serum levels of prealbumin (0.09±0.06g/L),and albumin(38.81±4.10g/L),C3(0.80±0.41g/L.),C4(0.18±0.17g/L) and CHE(5920.42±1403.73U/L)and lowest serum levels of total bile acid(215.95±155.24μmol/L).Conclusions:In comparison to other hepatitis,patients with hepatitis E had more serious hepatic injury.PartⅢ:Analysis of the quality of acute hepatitis net report in Minhang district in Shanghai in 2005.Objective:To analyze the quality of acute hepatitis net report in Minhang district in Shanghai in 2005.Methods:The information of acute hepatitis reports on China information system for diseases control and prevention of Minhang district in Shanghai from January to December in 2005 and the the medical records of the acute hepatitis cases in Shanghai 5th People's Hospital,Fudan University were collected to analyze the report quality by some indexes such as report ratio,in time ratio,completion ratio,correction ratio,exact reportion ratio.Results:The report ratio of acute hepatitis net report in Minhang district in Shanghai in 2005 was 100%,and the in time ratio was 92.79.The in time ratio of the second order hospitals were higher than of the community hospitals.The information of the patients' unit of work was seriously absent,while there was partly patients' telephone number absent.The in time correction ratio of hospitalize patients was 76.87%,while the exact reportion ratio was 65.5%.Conclusions:The quality of acute hepatitis net report in Minhang district in Shanghai in 2005 was good,and the exerted problem was the error reportion caused by error diagnosis.