Injury Su Kang Coating Liquid Pharmacodynamic Study

Objective:To clarify the mechanisms of SHANGSUKANG to treat mice on acute soft-tissue injury.Methods:One hundred and twenty healthy mice are divided into four groups with each group ten mice using random and parallel control methods.They are blank control group,SHANGSUKANG model group(0.1),SHANGSUKANG model group(0.2) and positive control group.The animal model of auricular swelling was induced by dimethylbenzene, twist reaction was induced by acetic acid and the pain-test by hot-plate in mice were used to observe the therapeutic effects of SHANGSUKANG.Result:1.The SHANGSUKANG model group(0.1), SHANGSUKANG model group(0.2) and positive control group could effectively extended the twist reaction Latency induced by acetic acid(compared with the blank control group P＜0.05),SHANGSUKANG model group(0.2) and positive control group strong effect in the SHANGSUKANG model group(0.1)(P＜0.05).2.The SHANGSUKANG model group(0.1), SHANGSUKANG model group(0.2) and positive control group could significantly reduce the twist reaction number induced by acetic acid(compared with the blank control group P＜0.01),SHANGSUKANG model group(0.2) and positive control group obviously strong effect in the SHANGSUKANG model group(0.1)(P＜0.01).3.The SHANGSUKANG model group(0.1),SHANGSUKANG model group(0.2) and positive control group could effectively improve the pain threshold in mice(compared with the blank control group P＜0.05), SHANGSUKANG model group(0.2) and positive control group strong effect in the SHANGSUKANG model group(0.1) (P=0.028,P=0.010).4.The SHANGSUKANG model group(0.1), SHANGSUKANG model group(0.2) and positive control group could significantly reduce the auricular swelling induced by dimethylbenzene(compared with the blank control group P＜0.05),SHANGSUKANG model group(0.2) and positive control group obviously strong effect in the SHANGSUKANG model group(0.1)(P=0.012,P=0.018).Conclusion:SHANGSUKANG shows obvious therapeutic effects in mice with acute soft-tissue injury and it might be an ideal external used drug in treating acute soft-tissue injury.