Diarrhea-predominant Irritable Bowel Syndrome Quality Of Life Status And Relationship With Tcm Syndromes Discussed

Objective:To investigate the health—related quality of life(HRQOL) in diarrhea irritable bowel syndrome(D-IBS) patients and its influencing factors, expecially to explore the relationship between Chinese Medicine syndrome and QOL.Methods:First of all, the part of literature review has collected and summari zed the understanding of the aetiology, pathology and treatment method of Irritabl e Bowel Syndrome (IBS) in Traditional Chinese Medicine (TCM) both in ancient times and in present age. Then another thesis has sum up the present research situ ation of modern medical science about the etiology and pathogenesis of diarrhea (I BS). In the clinical research part, we carried on the strict clinical research design based on the related standard,68 suitable cases of diarrhea irritable bowel syndrom e were selected in Combination of Clinical Practice and typed in 6 typesbased on syndrome differentiation, such as liver-stagnation and spleen-deficiency,weakness o f-spleen and stomach,yang deficiency of kidney,cold-dampness in the spleen,da mp-heat in the large intestine,accumulation of blood stasis. Using the Irritable bo w-el syndrome specific quality of life scale (IBS-QOL) to evaluate 68 patients'qu ality of life. Then to compare with the healthy subjects,respectively from dysphori a (DY), interference with activity (IN), body image (BI), health worry (HW), food avoidance (FA), social reaction (SR), sexual(Sx), and relationships (RL) eight poi nts. And to analysis the impacti on QOL from six factors, including sex. age. ed ucation,course,severity of symptoms, anxiety and depression, and to investigate t he relationship between Chinese Medicine syndrome and quality of life.Results:The IBS-QOL scores of eight directions, especially in food avoidance (FA), health worry (HW), dysphoria (DY), interference with activity (IN), in IBS patients were significantly lower than those in healthy people (P<0.01). No significant difference between men and women(P>0.05), gender and quality of life was no correlation on total score; except interference with activity (IN),sexual(Sx),relationships (RL) areas, there are no significant differences in each age groups(P>0.05); there's a negative correlation between age and QOL between on the total score; patients with different educational level have different point(P<0.05), educational level and quality of life score have positively correlation; No significant difference between difference course of disease, that was no correlation between the course and QOL on total score(P>0.05); different symptom severity were significantly difference(P<0.01), the symptom severity and quality of life have negative correlation; patients with different anxiety have different point on QOL; expect health worry (HW), the various differences between patients with depression(P<0.05); there are negative correlation between anxiety scale scores and quality of life score, also between depression scale scores and quality of life score. In interference with activity (IN),food avoidance (FA),social reaction (SR) dimensions and total score, anxiety and depression in patients with integral low-exist(P<0.05); liver-stagnation and spleen-deficiency, weakness of spleen and stomach patients both have significantly difference during each point of quality of life(P<0.01); liver-stagnation and spleen-deficiency patients have lowest points on health worry (HW); weakness of spleen and stomach patients have lowest points on food avoidance (FA); liver-stagnation and spleen-deficiency,damp-heat in the large intestine and accumulation of blood stasis in anxiety performance positive more than negative; and liver-stagnation and spleen-deficiency,damp-heat in the large intestine and accumulation of blood stasis in Psychological abnormalities were significantly more than normal. Conclusions:Quality of life decreases in IBS patients and its main influencing factors are educational level,severity of symptoms,intestinal symptoms and mental status; sex and age could affect the IBS QOL is in dispute, course of disease does not affect the quality of life of patients.It has some relationship between Chinese Medicine syndrome and Quality of life in IBS; Chinese Medicine syndromes could affect mental function of quality of life.