Angiotensin-converting Enzyme 2 Gene G-8790A Polymorphism With Essential Hypertension And Metabolic Syndrome Investigate

ObjectivesEssential hypertension (EH) and metabolic syndrome (MS) are complex disease that are caused by multiple genetic and environmental factors. Renin-angiotensin system plays an important role in the pathogenesis of EH. As an important component of RAS, many studies have reported that the polymorphisms of Angiotensin I converting enzyme 2 (ACE2) gene are strongly associated with EH. Here we performed a population based case-control study to analyze the relationship of G-8790A polymorphism in intron 3 of ACE2 gene with the development of EH and MS in ShanXi Han population.Methods127 hypertensive cases,109 hypertensive cases with metabolic syndrome and 100 normotensive subjects from ShanXi Han population were collected. G-8790A in ACE2 gene was genotyped by PCR-RFLP.ResultFor ACE2 gene located on chromosome X, data for each sex were analyzed separately. In female subjects, the frequencies of G-8790 alleles in EH patients, EH+MS patients and control subjects were 53.7%,42.1% and 58.0%, respectively, In male subjects.the frequencies of G-8790 alleles in EH patients, EH+MS patients and control subjects were 49.3%,47.5% and 52.0%, respectively. There was no significant difference for the frequencies that were found among different G-8790A genotypes or alleles either in woman (χ2=5.551, P=0.062), or in man (χ2=0.418, P=0.812). Female hypertensive patients with metabolic syndrome who carry the GG genotype had a significantly higher diastolic blood pressure compared with AA genotype. (P<0.05)ConclusionOur study provides no evidence for the association of G-8790A polymorphism in ACE2 gene with zailin essential hypertension with or without metabolic syndrome. Woman patients carrying GG genotype in EH with MS group might have higher diastolic blood pressure.