C-reactive Protein In Orthopedics, Perioperative Monitoring Of Significance

Objective:To observe the differences of CRP between the patients, who were within internal fixation and without internal fixation on the first and the third day after the orthopedic operation. Finding out the tendency during two weeks after the orthopedic operation that within internal fixation.Method:54 patients were divided into two groups; one is 36 patients who were within internal fixation, while the other 18 patients were without internal fixation. C-reactive protein (CRP) was examined on the first and the third day after operation among the 54 patients, and on the fifth, the seventh, the tenth and the fourteenth day after operation among the 36 patients who were within internal fixation. CRP was examined by immunoturbidimetry (ITM). Its normal level should be less than 10mg/L.Results:Comparing with the level of CRP before operation, there was obvious difference among these 54 patients on the first and the third day (P<0.05). And there was also obvious difference between who within internal fixation and without internal fixation on the first and the third day after the orthopedic operation(P<0.05). The level of CRP among the 36 patients within internal fixation was increased on the first day after operation, up to the peak on the third day, and then obviously decreasing on the fifth day; on the seventh day, the level of CRP was about or less than 50% that of the third day; when on the fourteenth day, the level of CRP was decreased the same as that before operation, or even less than that. The level of CRP was not obvious difference between male and female (P>0.05),but obvious difference among the means of orthopedic operation. Used or not bone cement on the arthroplasty, the level of CRP was not obvious (P>0.0)Conclusion:The levels of CRP were higher than before orthopedic operation on the first and the third day among the 54 patients, and those who within internal fixation were both higher than within internal fixation's patients on the first and the third day. There was also a tendency during two weeks after operation among those within internal fixation patients. Meanwhile, the changing of the CRP levels was different from the means of orthopedic operation. The more operative trauma, the higher of CRP level was. There was no association with gender of the CRP level. It would be good for discovering and interfering in secondary infection and complication if the CRP monitoring could be used during the period of before and after the orthopedic operation.