Mangrove Plants Aegiceras Bacteria Streptomyces Sp. The Chemical Composition Of The Fermentation Broth

The secondary metabolites of marine microorganism show diversities in structure and activity because of particularity in their living environment. In order to investigate the metabolites with novel structure and potential bioactivity,we have systematically investigated the chemical constituents and bioactivity of the microorganism Streptomyces sp. which was separated from mangrove plant Aegiceras corniculatum.On the basis of silica gel column chromatography, Sephadex LH-20 column chromatography, ODS column chromatography and HPLC, fifteen pure compounds involving five new compounds were obtained from this marine microorganism. Their structures were determined by extensive spectroscopic analysis, including NMR, MS, IR, UV spectra, which are (2E)-11-(4'-aminophenyl)-5,9-dihydroxy-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (1*), 9-(4'-aminophenyl)-3,7-dihydroxy-2,4,6-trimethyl-9-oxo-nonoic acid (2*), (2E)-11-(4'-aminophenyl)-5,9-O-cyclo-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (3*), 9-(4'-aminophenyl)-3,7-O-cyclo-2,4,6-trimethyl-9-oxo-nonoic acid (4*), 9-hydroxy-3-(hydroxymethyl)-4-(1H-indol-3-yl)-8-(methylamino)isochroman-1-one (5*), 3,3-bis(3'-indolyl)propane-1,2-diol (6), methyl-2-(1H-indol-3-yl)acetate (7), 1H-indole-3-acetic acid (8), indole-3-carboxylic acid (9), methyl-2-(2-hydroxyphenyl)acetate (10), 4-hydroxybenzoic acid (11), (2E)-3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid (12), (2E)-(4-hydroxyphenyl)-2-propenoic acid (13),2-hydroxy-benzene acetic acid (14), cyclo(phenylalanyl-seryl) (15).