Study On Synthesis Of Cyclodextrins Modified Magnetic Nanoparticles As A Drug Carrier

Drug carriers were used for improving the properties of slightly water-soluble drugs. For example:their low solution, their bioavailability, side effects and so on.Cyclodextrins and their derivatives have been widely used as drug carriers due to their hydrophobic cavity, besides non-toxic and stability. Owing to the specific magnetism of magnetic nanoparticles, they can be modified by polymers to form drug carriers. Cyclodextrins modified magnetic nanoparticles as drug carriers have many advantages, Cyclodextrins can improve the dissolution and stability of hydrophilic drugs. On the other side, the system possessed magnetism because of magnetic nanoparticles, allow the delivery of drug to the desired target area and fixing them at the local site. The study of drug carrier has important theoretical significance and great value of practicality. Study on the perparation and characterization ofβ-cyclodextrin modified Fe3O4 magnetic nanoparticles as a drug carrier in this thesis, the results as follow:1,Fe3O4 magnetic nanoparticles were Prepared with the method of co-precipitation and the dynamic light scattering revealed that they had a mean hydrodynamic diameter of 43.2 nm. Then was modified by gum arabic and was fabricated by grafting the (3-cyclodextrin which was modified by citric acid already. Thermogravimetric analysis indicated that the percent of gum Arabic used for modified Fe3O4 magnetic nanoparticles was 7.09%, the percent of (3-cyclodextrin bonded Fe3O4 magnetic nanoparticles core-shell was 6.50%,the number was about 122.2,Using ketoprofen as a model drug, preparation of ketoprofen/Fe3O4-(3-cy--clodextrin inclusion complexesvia ultrasonie method.The method for the determination of ketoprofen was established, by UV-visible spectrophotom--etry, the results were that:R=0.99993,the RSD of Precision were less than 1%, the rate of Recovery were between 81%and 91%, their RSD were also less than 1%, the investigation show that the method with highly precision and accuracy.3,The water-solubility of ketoprofen influenced by the drug carrier of Fe3O4-(3-cyclodextrin was investigated, the results show that the solubility of ketoprofen was improved double owing to the drug carrier of Fe3O4-(3-cyclodextrin. The condition of adsorption data were obtained by Langmuir isotherm equation, the maximum loading of ketoprofen by Fe3O4-β-cyclodextrin was 615 mg/g, Langmuir adsorption equilibrium constant KL was 0.0018 L/mg. Calculating the inclusion rate of ketoprofen by Fe3O4-β-cyclodextrin was from 20%to 40%.4,Calculating the rate of inclusion and loading drugs of the drug carrier of Fe3O4-β-cyclodextrin were 32.18%and 39.49%, respectively. However, the rate of inclusion and loading drugs of the drug carrierβ-cyclodextrin were 67.66%and 8.58%, respectively. Obviously, the drug carrier of Fe3O4-β-cyclodextrin had highly loading drugs due to a lot ofβ-cyclodextrin. The dissolution curve of ketoprofen-Fe3O4-P-cyclodextrin showed that ketoprofen dissolved rapidly in the first 20 minutes, the rate was about 78.6%, that indicated that this system seems to be a very promising vehicle for the administration of hydrophobic drugs.