Application Of Serum Cys C,Urinary NAG In Clinical Significance Of Early Diabetic Nephropathy

Objective:To investgate the clinical significance of eystatin C (Cys C),Urinary N-acetyl-D-glucosaminidase (NAG) in the degree of diabetic nephropathy. Methods:113 cases with type2 diabets admitted into our hospital were enrolled into my retrospective study, they are divided into three groups according to UAER levels, including diabetes mellitus without albuminiria, microalbuminiria macroalbuminiria. Common characters were recoded such as sex, age, smoking status.All subjects were measured Urinary albumin rate,N-acetyl-D-glucosaminidase (NAG),Glomerular filtration rate (GFR). Results:(1) The level of eystatin C, NAG are much higer in microalbuminiria goup and macroalbuminiria group than that of diabetes mellitus without albuminiria group; The level of eystatin C,NAG are much higer in macroalbuminiria group than that of microalbuminiria goup; (2) There was a positive correlation between eystatin C and Serum creatinine (Scr),Urinary albumin rate and Schwartz was 0.741,0.617, (P<0.01), There was a negative correlation between eystatin C and Glomerular filtration rate (GFR) and Schwartz was-0.606 (P<0.01), The correlation between NAG and Serum creatinine (Scr) .Urinary albumin rate, GFR was 0.558,0.617,-0.524 (P<0.01); (3) The study showed AUCROC of eystatin C is larger than that of Scr, and similar to that of UAER. Conclusions:cystatin C,NAG could be used to as sensitive indicator for damage in kidney of diabetes.