The Analysis Of Clinical Characteristics And Prognosis Of 32 Triple-negative Breast Cancer

Objective:Triple-negative breast cancer(TNBC) represents the subset of breast cancer with aggressive biological behaviors and poor prognosis. It appears early recurrence and metastasis and is not likely to benefit from antioestrogen or anti-HER2 therapy, and in consequence received a wide publicity. To explore the prognostic risk factors of TNBC patients of this area and to strive to provide a basis for carrying out individual treatment, we analysis the clinical characteristics, prognostic factors and survival differences of 295 cases of TNBC and non-TNBC retrospectively in univariate and multivariate aspects in this study. Methods:We studied a cohort of 295 female patients with breast cancer, diagnosed between January 2005 and January 2011 at the Xin Jiang provinse Chinese-Trditional Hospital. All of the patients underwent surgery and received antioestrogen therapy, adjuvant chemotherapy and radiotherapy normatively. We used SPSS 17.0 statistical software package to sort and analyze the data of 295 cases of breast cancer patients and selected characteristic clinical indicators (age at onset, menstrual status, tumor size, TNM stage, clinical stage, whether triple-negative or not, number of positive lymph nodes, chemotherapy。al, overall survival, metastatic sites, etc.), then according to SPSS17.0 package and processing requirements, we quantified these and used x2 to test the count data of clinical indicators, takingp<0.05 as statistical significant and P<0.01 as conspicuous significant statistical. Results:This study involved 295 cases of breast cancer patients, including 32 cases of TNBC which accounts for 10.85%and most of its pathological type is invasive ductal carcinoma. TNBC and non-TNBC both have a high incidence of middle-aged and the incidence rate of old-age group is low. TNBC onsets in women of all ages both before and after menopausal. TNBC patients are more likely to have lymph node metastasis (P<0.05), and the local recurrence and distant metastasis rates are significantly higher than non-TNBC patients (P<0.05). Furthermore, metastasis in bones is more likely to occur than in organ. But there is no statistical difference exists in the distribution of tumor size, clinical stage of TNBC groups. By the end of follow-up,7 cases (21.88%) of 32 TNBC patients died and 27 cases (10.27%) of263 non-TNBC patients died. The disease-free survival curves (Figure 3.1) has aconspicuous statistical significant between TNBC and non-TNBC, P<0.01, and the overall survival curve (Figure 3.2) has a significant statistical significant, P<0.05. Conclusion: TNBC has strong aggressive and the number of metastasis lymph node, local recurrence and distant metastasis rate of TNBC are significantly higher than non-TNBC. Metastasis in bones is more likely to occur than in organ. Its prognosis is poor and worse with late age of onset, late clinical stage and large number of positive lymph node. The tumor size and the number of metastasis lymph node are the independent prognostic factors for TNBC patients.