The Expression Of Survivin And Fas In Epithelial Ovarian Cancer And Its Clinical Value

Background and ObjectivesMalignant ovarian tumors are one of cancers of the female reproductive system. Its morbidity is second only to cervical cancer and endometrial cancer, but malignant ovarian tumors have the highest mortality rate. Epithelial ovarian cancer accounts for 85-90% of ovarian cancer. It usually grows rapidly, being highly malignant and easy to transfer and spread, and so the prognosis is poor. It is serious threat to the life and health of women, so we put it as the main object of study in ovarian cancer. In this experiment, we study the expressions of survivin and fas in different ovarian tissues, their relationships with clinic pathological parameters in ovarian epithelial cancer and the correlation between the two proteins in order to clear epithelial ovarian cancer pathogenesis, which may provide theoretical basis for prevention and treatment.Materials and MethodsImmunohistochemical staining (S-P) assay was used to measure the expression of survivin and fas protein in each of 20 cases of ovarian normal tissue,30 cases of benign epithelial ovarian tumors and 48 cases of epithelial ovarian cancer tissues.Results1 The expression of survivin:Compared with normal ovarian tissues survivin, the expression of survivin in ovarian epithelial cancer tissues was significantly higher, and the difference was statistically significant (P<0.001). The expression of survivin in ovarian epithelial tumor was closely related with surgical-pathologic stage, histologic grade and lymph node metastasis. In epithelial ovarian tumors, stageⅠ～Ⅱ,Ⅲ～Ⅳpositive expression rate of survivin were 56.5% and 96.0% respectively, and there was a statistically significant difference (P<0.05); In well-differentiated epithelial ovarian tumors (G1-G2 phase), the positive expression rate of survivin was 61.6%, which was significantly lower than it in poorly differentiated epithelial ovarian tumors (G3 period). Its positive expression rate was 90.9%, and the difference was statistically significant (P<0.05); The positive expression of survivin in patients without lymph node metastasis was significantly lower than that in patients with lymph node metastasis (P<0.05)2 The expression of fas:The expression of fas in normal ovarian tissue was significantly higher than that in ovarian epithelial malignant tumors, and the difference was statistically significant (P<0.05). Relationship between Fas in epithelial ovarian cancer tissue and surgical-pathologic stage or histologic grade close: in malignant epithelial ovarian tumors, stageⅠ～Ⅱ,Ⅲ～Ⅳpositive rate of Fas were 78.3% and 15.0%, respectively, and the difference was statistically significant (P<0.05); in well-differentiated epithelial ovarian cancer (G1～G2 phase), the positive expression rate of Fas was 69.2%, which is significantly higher than that in poorly differentiated epithelial ovarian malignancy tumors (G3 period). Its positive expression rate was 19.1%, and the difference was statistically significant (P<0.05); There was no significant difference about fas expression between patients with lymph node metastasis rate and patients without lymph node metastasis rate.3 Correlation analyses:Survivin and fas in epithelial ovarian cancer was negatively correlated with the expression:r=-0.365, P<0.01Conclusions1 Survivin and Fas were related to the occurrence and the development of epithelial ovarian cancer.2 The expressions of Survivin and Fas in epithelial ovarian cancer were correlated with clinical stage and histologic grading.3 Survivin and Fas in epithelial ovarian tumors were negatively correlated. They played a synergistic effect, in the tumors'occurrence and development.