Effects Of Xingding Injection On The Microinflammatory State Of Chronic Renal Failure

Objective:Ob Servation of Xingding injection on chronic renal failure micro-inflammatory state, and to explore effective drug treatment of CRF.Method:Observed cases of 60 patients with chronic renal failure patients were selected CKD3-4 stage, detection of hs-CRP greater than 3mg/1, and the exclusion of the primary disease is vasculitis, SLE, mixed connective tissue disease and thyroid disease, gastrointestinal Tract disease, viral hepatitis, malignancy, recent infection, open parallel randomized controlled trial, were randomly divided into two groups:Xingding injection group (treatment group) and control group,30 cases in each.Conventional treatment were treated by western medicine, give a low salt low-fat quality low-protein diet, and according to the conditions of patients given received alimta, including control blood pressure, anti-infection, correct water electrolyte and acid-base imbalances, correct anemia, improve heart function, regulating calcium phosphate metabolic disorder, etc.; The western medicine treatment group in the control group based on conventional treatment combined with apricot butyl 30ml+0.5% glucose (injection for xylitol) diabetes 250ml 1 time/day. Two groups of course are three weeks.Test before and after the treatment of two groups of patients treatment of allergic c-reactive protein (CRP), hs-ALB, TC and TG, HDL, LDL, Lp (a) and (Scr), BUN, etc, index, and record the before and after the treatment of patients with clinical symptoms and signs, make changes effect assessment.Result:1. Xingding injection total effective rate of the treatment group 70.00% group and intellectual, the treatment group than controls (p<0.05) high. Experimental results show that:the apricot butyl injection chronic renal failure micro inflammation of state has a better treatment effect and overall efficacy than control group.2. Xingding injection after treatment group and control group of TCM treatment were significantly symptom scores decline, two groups compared with before treatment are significant difference (P<0.05), and the treatment group was better than control group (P<0.05).3. Xingding injection after treatment, lowering hs-CRP, ALB increased compared with the control group and both were significantly different (P<0.05); treatment group and control group after treatment, BUN, Scr decreased more There was a significant difference between the former (P> 0.05).The results show that Xingding micro-injection can inhibit inflammation, retard deterioration of renal function.4. The treatment group after treatment, the TC, TG, LDL and HDL, Lp (a) all have improved, no significant change in the placebo group. Show xingding injection can significantly improve blood lipid levels.Conclusion:Xingding injection can reduce inflammatory factors in patients with chronic renal failure, CRP, improve the micro-inflammatory state, increased ALB, improve lipid metabolism (TC, TG, LDL, HDL, Lp (a)), to improve fatigue in patients with fatigue, eat less Poor appetite, weak waist, limbs heavy storm, looking gloomy, low back pain, clinical symptoms such as skin a mistake that Xingding Injection on protect the kidneys, the further injury of renal function and improve quality of life of patients and improve the prognosis of a positive Effect.