The Influence Of Hemoperfusion On Microinflammatory State In Acute Renal Failure Patients

Objective:To observe levels of serum inflammatory factors,such as C reactive protein(CRP), interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and effect of hemoperfusion(HP) removing inflammatory mediators of middle and giant molecules on acute renal failure(ARF) patients.Methods:76 simple ARF patients(without acute or chronic infection,malignancy,multiple organ failure,treatment with glucocorticoid and immunosuppressant,history of blood transfusion)were randomly devided into hemoperfusion combined with hemodialysis group (HP+HD group,n=38)and hemodialysis group(HD group,n=38),all patients were drawn blood before and after treatment respectively.Normal control group consisted of 25 healthy people. Serum CRP,IL-6 and TNF-αlevels were determined by ELISA.Results:Serum CRP,IL-6 and TNF-αlevels in treatment groups were significantly higher than those in control group(P＜0.001),and those were no difference between two treated groups before treatment(P＞0.05);The levels of CRP,IL-6 and TNF-αhad significantly positive correlation in three groups before treatment(P＜0.001);Serum CRP,IL-6 and TNF-αlevels decreased after treatment than those before treatment,and those had statistic significance in HP+HD group(P＜0.001),but not in HD group(P＞0.05).Conclusions:There are high levels of microinflammatory factors such as CRP,IL-6 and TNF-αin ARF patients,which perhaps indicates there is microinflammatory state in ARF patients.The study also suggests that hemoperfusion is an effective method to remove increased inflammatory factors in ARF patients.