Clinical Significance Of DCR3 In Patients With Hepatocelluar Carcinoma

Objective: To investigate the diagnostic value andclinical significance of elevateddecoy receptor 3(DcR3)in patients with hepatocellularcarcinoma(HCC).Methods: Serum DcR3 levels were measured using enzyme-linked immunosorbent assay(ELISA) in 45 patients with HCC and in the healthy individuals.The expression of DcR3 in HCC tissue was evaluated by immunohistochemistry(IHC).Reverse Transcription Polymerase Chain Reaction(RT-PCR) is used to evaluateThe expression of mRNA about DcR3Results: The levels of serum DcR3 in HCC patients were higher than that in healthy individuals (P<0.01).The level of serum DcR3 in HCC patients was correlated with the development of cirrhosis(P<0.05).There was a positive correlation betweenthe levels of DcR3 in the serum and HCC tissue(r=0.395,P<0.01). The positive rate of DcR3 inthe serum was significantly higher than that in HCC tissue(P<0.05). DcR3 is negative in the neighboring tissue around The sensitivities of single. The expression of mRNA about DCR3 and DCR3 protein expression basically consistent, is negative in the corresponding neighborly tissue around HCC. But its positive 71.1 percent (32/45) is between serological level 75.6% (34/45) and histological level 60 percent (26 / between 45). Conclusions: Elevated DcR3 may play an important role in the pathogenesis,development,invasion and metastasis of HCC.It may be of great significance for the screening,diagnosis and prognosis of HCC to simultaneously monitor the levels of DcR3 expecially in the serum level of high-risk populations and HCC patients.