The Association Of TXNIP With Type 2 Diabetes And Insulin Resistance

Objective :To explore the association of thioredoxin-interacting protein(TXNIP) with type 2 diabetes and insulin resistance.Methods: Fasting serum TXNIP concentrations was measured in 54 patients with type 2 diabetes mellitus(T2DM) and 30 normal controls by using enzyme-liked immunosorbent assay. Glycosylated hemoglobin A1c (HbA1c),body mass index (BMI),wais(tW),waist-to-hip ratio (WHR),totle cholesterol (TC),triglyceride (TG), high density lipoprotein (HDL-C),low density lipoprotein (LDL-C),insulin (INS) and fasting plasma glucose (FPG) were also measured in fasting status. According to BMI,patients with type 2 diabetes were divided into two groups, obese group(T2DM-OB) and normal weight group(T2DM-NW). Statistical analyses were performed with the use of SPSS13.0 software. We investigated the changes of serum TXNIP in different groups and its association with other clinic index.Results: (1) Serum TXNIP level was higher in T2DM group than normal control group(P<0.05). But there was no difference between T2DM-OB group and T2DM-NW group(P>0.05). (2) Pearson correlation analyses showed that TXNIP was positively correlated with FPG,HbA1c,HOMA-IR (P<0.01)(.3)Multiple linear regression analyses showed that HbAIC,HOMA-IR were independent determinants for serum TXNIP concentrations.Conclusion:TXNIP was strongly associated with type 2 diabetes and insulin resistance. It may play a very important role in the process of developing type 2 diabetes and insulin resistance.