| PurposeUsing contrast experiment method, observation of Toutongning combined with flunarizine capsules in the treatment of migraine disease curative effect and biochemical indexes; comparison of Toutongning capsule combined with flunarizine capsules in the treatment group and the control group treatment of migraine flunarizine in the process, the therapeutic effect of cerebral artery blood flow velocity, serum levels of K+, Na+, Mg2+,CI+ concentration, MEK concentration, CGRP concentration effect.MethodSelected 68 eligible patients were randomly divided into two groups, contrast experiment. Respectively Toutongning combined with flunarizine in treatment group and flunarizine in control group. Among them, Toutongning combined with flunarizine in treatment group and flunarizine group cases were 44 cases and 24 cases.Headache Ning and flunarizine in treatment group:selection of Shaanxi Xianyang Pharmaceutical Company Limited (batch production step Z20026851) of the 1.2g Toutongning capsule,3 times daily,3 capsules each time, Xi'an pharmaceutical company Yang Sen (batch 071102937) flunarizine capsules 5mg, every night 2;Flunarizine group:selection of Xi'an Yang Sen pharmaceutical company (batch 071102937) flunarizine capsules 5mg, every night 2;Two to 30 days for a treatment cycle were observed, observed the week before and 30 days after treatment of headache severity, before and after treatment were observed, detection of blood flow of vascular function in experimental observation, serum K+, Na+, Mg2+, CI+ was observed, MEK concentration, CGRP content comparison.ResultHeadache Ning and flunarizine in treatment group, the group of two groups before treatment of sex, age, course of disease and so on the basis of clinical situations each index compare difference not to have statistical significance (P>0.05), comparable to;After 30 days of treatment:Effects of Toutongning, combined with flunarizine in total effective rate in the treatment group was significantly higher than that of flunarizine group, P=0.028, the statistical results there was significant difference;Headache severity comparison, Toutongning combined with flunarizine in treatment group is better than that of flunarizine group:Toutongning combined with flunarizine in treatment group symptoms improve the total efficiency of 90.90%, the efficacy rate was 27.30%, basic cure rate 43.20%; flunarizine controls symptoms improve the total efficiency of 79.17%, the efficacy rate was 20.83%, the cure rate 45.83% basic headache; Ning and flunarizine in treatment group total effective rate, cure rate, significantly higher efficiency of flunarizine in control group, P=0.028, the statistical results there were significant differences, with statistical significance;Transcranial Doppler blood flow velocity detection and analysis of TCD, Toutongning and flunarizine in treatment group was significantly better than flunarizine group, P<0.05, the statistical results there was significant difference. MCA (middle cerebral artery):77.1+17.6+12.5 VS 85.4+18.6; ACA (anterior cerebral artery):57.2+11.2 VS 61.2+11.2; PCA (posterior cerebral artery):52.8+ 14.6 VS 58.6+14.5; BA (basilar artery):44.5+7.7 VS 49.6+9.1; VA (bilateral vertebral artery):40.1+7.8 VS 42.3+7.5;Electrolyte ion concentration, Toutongning and flunarizine in treatment group compared with flunarizine group, K+ concentration decreased, increased concentration of Mg2+ amplitude is more obvious, (4.65+0.32 VS 5+0.2), (0.80+0.04 VS 0.66 +0.04), P<0.05, the statistical results showed significant difference; Comparison of MEK concentration, Toutongning and flunarizine in treatment of group MEK significantly lower concentrations of flunarizine in group MEK concentration, (28.65+18.32 VS 38.65+19.98) P<0.01, there were significant differences, with statistical significance;Before and after treatment with CGRP, Toutongning and flunarizine in treatment of group EJV, CF than flunarizine group decreased significantly, (EJV:34.26+11.25 VS 45.62+9.25; CF:30.12+7.255 VS 33.12+7.34), P< 0.01, while further study found that headache, EJV CGRP in blood was significantly elevated, CF CGRP had no significant changes in blood.ConclusionHeadache Ning and flunarizine in treatment group basic cure rate was 43.20%, markedly effective rate was 27.30%, the total efficiency of 90.90%, and flunarizine group basic cure rate was 45.83%, markedly effective rate was 20.83%, the total efficiency of 79.17%, there was significant difference.. From the aspect that Toutongning and flunarizine capsules in the treatment of migraine is better than flunarizine capsules, on the other hand also proved Toutongning capsule with two drugs can be combined with flunarizine. The two drugs either single or combined with no obvious adverse reaction, which can be proved by Toutongning capsule is a safe and effective treatment for migraine medication, it is worthy of clinical application. |
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