A Random And Compared Research Of Qing Re Jie Du Method On Gastric Precancerous Lesion And The Expression Of P53, Ki67, APC Protein

Objective Evaluate the safety and effect of Qing Re Jie Du method which composes of Bai Hua She She Cao, Ban Zhi Lian and E Zhu on gastric precancerous lesion, and discuss the effect of this approach on P53,Ki67,APC protein of the precancerous lesion tissue.Method A random and compared method is used. All patients with gastric precancerous lesion are divided randomly into two groups and applied Qing Re Jie Du herb therapy or folacin therapy separately. The treatment period lasts 6 months. Note the symptom change, drug combination, security in the treatment period. Gastroscope, pathology, immunohisto-chemistry examination are taken on patients before-therapy and after-therapy, to evaluate the integral change of gastroscope, pathology and the expression change of P53, Ki67 and APC protein.Result:52 patients join in this research,42 patients finish 6-month therapy. There are no significant difference between the two groups in sex, age, drug combination, Hp infection and integral of symptom, gastroscope, pathology and the expression of P53, Ki67 and APC protein before therapy. The symptom integral of the two groups both decreases after therapy, but only herb therapy group has statistic meaning(P<0.05).Combination drug is used in both groups, the control group has more patients than herb therapy group, the comparison has statistic meaning(P<0.05). There is no adverse reaction during the treatment period. After 6-month therapy, the integral of atypical hyperplasia, atrophy and intestinal metaplasia is obviously decreased in both groups, has statistic meaning comparing with before-therapy (P<0.05), while the integral of inflammation, reactiveness and gastroscope has not changed much after therapy (P>0.05). The change of pathology doesn't have statistic meaning between the two groups. The expression of P53 and Ki67 protein has increased and APC protein has decreased in the tissue of precancerous patients. But after 6-month treatment, the expression of P53 and Ki67 protein has descended significantly in both groups comparing with before-therapy (P<0.05), while APC protein has not changed much (P>0.05).The change of P53, Ki67, APC protein is without statistic meaning between the two groups after therapy.Conclusion:The Qing Re Jie Du method has a safe and favourable effect on gastric precancerous lesion, which can improve the uncomfortable symptoms of patients and can invert the lesion of atypical hyperplasia(56.25%), atrophy(35.50%) and intestinal metaplasia(25.68%) on a certain extent. The Qing Re Jie Du method may decrease the expression of P53 protein for which descend the activity of cell multiplication to prevent precancerous lesion.