Research On Calcium Magnesium Bioactive Materials For Bone Regeneration

In this study, two calcium-magnesium based biomaterials were fabricated for bone repair. Magnesium substituted calcium phosphate cement (MCPC) was fabricated by adding active magnesium oxide into tetracalcium phosphate and calcium hydrogen phosphate, and MCPC porous scaffolds were prepared through particle leaching method. The scaffold shows excellent in vitro biodegradability and cell compatibility. We implanted the scaffold into rabbit femur defect, and the scaffold degraded and new bone generated with time. After 12 weeks, the scaffold degraded completely and the defect was repaired.Ordered mesoporous calcium-magnesium silicate (OMC) was synthesized by sol-gel method. OMC possesses uniform mesochannals around 7 nm and a large surface area of 1017 m2/g. OMC has good solubility in Tris-HCl solution, after 7 days soaked in simulated body fluid (SBF), an apatite layer formed on the surface of the material, which indicate a good bioactivity. Implanted in rabbit femur defect, OMC showed good compatibility and degradability, the defect was healed after 12 weeks of implantation.In addition, both the animal experimental specimens of MCPC scaffold and OMC were restructured into 3D images in Shanghai synchron radiation facility (SSRF). The process of bone regeneration was observed clearly and directly.All the results indicate that both MCPC and OMC are potential biomaterials for bone regeneration.