Analysis Of Prognostic Factors In Nasopharyngeal Carcinoma Following Radiotherapy

Objective:the441nasopharyngeal carcinoma patients were retrospectively analysis, to investigate the prognostic factor for patients with NPC who received radiotherapy(RT)and to reference for clinical treatment.Methods:We retrospectively analyzed the Affiliated Tumor Hospital of Guangxi Medical University accepted the first diagnosed441cases of concurrent radical radiotherapy in patients with nasopharyngeal carcinoma,from January2003to December2007in age, gender, T stage, N staging,clinical stage and cranial nerve injury, radiation way the nasopharynx radiation dose, chemotherapy, and in2003the World Health Organization (WHO) pathological type and other factors on the prognosis.The Kaplan-Meier method was used to calculate of survival rate,Log-rank test was conducted to determine significance.Factors with statistical significance would be put into a multivariate COX regression model, when P<0.05that the difference was statistically significant. Results:(1) the441cases of patients with nasopharyngeal carcinoma forl,3and5years overall survival were92%,70%,58%,.respectively.(2) Univariate analysis showed that age (P=0.008), T stage (P=0.002), N stage (P=0.005), clinical stage (P=0.000), radiotherapy (P=0.003), cranial nerve injury (P=0.000) were significant prognostic factors.WHO pathological type (P=0.524) and non-keratinizing subtype (P=.681) in2003, the difference was not statistically significant.This study further stratified analysis of patients with nasopharyngeal carcinoma application2003WHO histopathological classification re-typing, compared the same clinical stage and whether chemotherapy and prognosis, the results show survival rates were not statistically significant.The same clinical stage and keratinizing carcinoma and undifferentiated nasopharyngeal carcinoma patients whether chemotherapy and prognosis, the results show survival rates were not statistically significant.(3) Multivariate logistic regression analysis showed that age (P=0.001), cranial nerve injury (P=0.011), radiotherapy (P=0.008) were independent factor affecting the prognosis of nasopharyngeal carcinoma.Conclusion:Age, T stage, N stage, clinical stage, radiotherapy, cranial nerve injuries were related to prognosis of nasopharyngeal carcinoma; and older, cranial nerve injury are the major poor prognostic factors. Intensity Modulated Radiaton is superior to Therapy3-Dimensional Conformal Radiation Therapy and conventional radiation, but this study, intensity modulated radiation therapy was too small to need to expand the sample size for further verification, pathological type in2003WHO was not related to prognosis of nasopharyngeal carcinoma, and the same clinical stage and whether chemotherapy were not related to prognosis.Further stratified analysis with the same clinical staging and non-keratinizing carcinoma undifferentiated nasopharyngeal carcinoma prognosis and whether chemotherapy was no correlation. The data into a skewed distribution between the two sets of data the number of cases, the need to expand the sample size for further studies.