Association Between The Concentration Of Plasma IL-6and The Chronic Obstructive Pulmonary Disease Combined With Osteoporosis

Objective To assese the association between the concentration of plasma IL-6and the chronic obstructive pulmonary disease with osteoporosis and to explore whether the plasma IL-6levels are associated with bone mineral density and FEV1%predicted value.Methods100male patients who were diagnosed as COPD according to the Institute of Respiratory Diseases, Chinese Medical Association. In accordance with the WHO diagnostic criteria, the COPD patients are further divided into two groups:the osteoporosis group (OP group) and non-osteoporosis group (NOP group).50healthy male subjects were selected as the NC group. The concentration of plasma IL-6was measured by ELISA. We analysed the relationship between IL-6and the BMD values, FEV1%predicted value.Results The concentrations of plasma IL-6were28.17±2.98pg/ml in OP,28.50±3.43pg/ml in NOP and23.14±2.46pg/ml in NC. There were statistically differences between the three groups(X2=61.712, P=0.000). Comparing NC group with the OP group, NOP group, the concentration of IL-6difference was statistically significant (P<0.05). Between OP group and NOP group, the concentration of IL-6difference was not statistically significant (P>0.05). Plasma IL-6concentrations and BMD values, FEV1%predicted value have no correlation (P>0.05). BMD was positively correlated with weight, BMI, and FEV1%predicted value (P<0.05).Conclusions Our data suggest that the concentration of plasma IL-6in OP and NOP group were higher. There was an association between the concentration of plasma IL-6and COPD. And the concentration of plasma IL-6might be not correlation with FEV1%predicted value and BMD. The concentration of plasma IL-6would not be a major risk factor for COPD combined with OP, which could be influenced by many factors. We should expand cases for further study. Weight, BMI, and FEV1%predicted value might be risk factors for COPD combined with OP. Objective To assese the association between IL-6-572C/G gene polymorphisms and the chronic obstructive pulmonary disease with osteoporosis; to explore whether the IL-6-572C/G gene polymorphisms associated with bone mineral density, FEV1%predicted value; anlysis of the role of IL-6-572C/G gene polymorphism on plasma IL-6and its incidence of COPD combined with OP.Methods100male patients who were diagnosed COPD according to the Institute of Respiratory Diseases, Chinese Medical Association. In accordance with the WHO diagnostic criteria, the COPD patients are further divided into two groups:the osteoporosis group (OP group) and non-osteoporosis group (NOP group).50healthy male subjects were selected as the NC group. IL-6of were genotyped by PCR-RFLP. We analysed the difference of the frequencies of genotypes and alleles of IL-6-572C/G gene polymorphisms between the OP, NOP and NC groups. We also analysed the relationship between IL-6-572C/G gene polymorphisms and the FEV1%predicted value, BMD value, and the influence on plasma IL-6levels and exolore whether its distribution are same with reported polymorphisms in other ethnic comparison.Results Genotype frequeney of IL-6-572CC, CG and GG were38%,44%,18%in OP group,54%,36%,10%in NOP group and68%,26%,6%in NC group. The C allele frequency in the OP group, NOP group and NC group was60%,72%and81%respectively; the G allele frequency in the OP group, NOP group and NC group were40%,28%and19%respectively. There were statistically differences both in genotype and in allele frequency between the three groups (P<0.05). A significant correlation between the IL-6-572C/G gene polymorphisms and the BMD values (P<0.05), no correlation between the IL-6-572C/G gene polymorphisms and FEV1%predicted value. Plasma IL-6levels in each genotype and allele differences was not statistically significant (P>0.05). IL-6-572genotype and allele frequencies and the results have been reported in this study population compared to prompt its distribution in different ethnic difference was statistically significant (P<0.05).Conclusions There might be an association between IL-6-572C/G gene polymorphisms and COPD combined with OP, which mechanism remains to be into-further research. The concentration of plasma IL-6was not statistically differences in case subjeets with IL-6genotype and allelle. The role of the IL-6gene-572C/G polymorphism in rising of plasma IL-6level in patients with COPD combined with OP will be further study. Objective To assese the risk factors of the chronic obstructive pulmonary disease with osteoporosis; to explore whether the age, weight, BMI, Ca, P, IL-6concentration, IL-6gene polymorphism (GG/GC/CC), FEV1%predicted value, the average partial pressure of oxygen, intravenous hormone, inhaled corticosteroids, smoking index, calcium intake is associated with COPD with OP.Methods Age, body weight, BMI, Ca, P, FEV1%predicted value, the average partial pressure of oxygen, intravenous hormone, inhaled corticosteroids, smoking index, time of sunshine and calcium intake were compare in OP, NOP and NC groups Were the use of ANOVA, Logistic multivariate regression analysis and factor analysis to explore the age, body weight, BMI, Ca, P, IL-6concentration, IL-6gene polymorphism (GG/GC/CC), FEV1%predicted value, the average partial pressure of oxygen, intravenous hormones, inhaled corticosteroids, smoking index factors in COPD with OP.Results Body weight, BMI, Ca, IL-6, intravenous hormone inhaled corticosteroid hormone total, FEV1%predicted value, the average partial pressure of oxygen and smoking index in the OP, NOP and NC three groups was statistically significant (P <0.05). Among the three groups, the other indicators were no difference (P>0.05). ANOVA analysis showed that body weight, BMI, FEV1%predicted value, the amount of inhaled corticosteroid, total of4factors. Logistic regression analysis showed that body weight, FEV1%predicted value, the amount of inhaled corticosteroid were statistically differences, were the risk factors of COPD with OP and were a significant correlation with osteoporosis. Factor analysis extracted five common factors:the first factors were intravenous hormone dosage and inhaled corticosteroid dosage; the second factor was IL-6concentrations; the third factors were body weight, BMI, and genotype grouping; the forth factor was FEV1%predicted value; the last factors were age and Ca.Conclusions The risk factors of the chronic obstructive pulmonary disease with osteoporosis were age, weight, BMI, hormone dosage, FEV1%predicted value, IL-6gene polymorphism (GG/GC/CC).