Evaluation Of Non-invasive Skin Test Method For Evaluating Moisturizer

Objective:To evaluate several non-invasive skin test method for assessing moisturizer efficacy. Methods:46subjects were randomly divided into two groups (moisture cream group and moisture freshener group) with using the moisturizers for4weeks. The skin hydration, Water Sorption-desorption test and TEWL were measured by Corneometer CM825(?)and Tewameter(?)at baseline and2,4weeks. Questionnaire for subjects self-estimation were collected. The skin hydration condition was also observed and scored by a dermatologist. Results:The skin hydration at cheek and mouth corner in two groups increased significantly with time (F=10.655, P<0.001, F=18.639, P<0.001;respectively). Sorption-desorption test show water-holding capacity in two groups increased significantly with time (F=6.354, P<0.01, F=7.230, P<0.01".respectively). TEWL value decreased significantly in moisture cream group (F=4.605, P<0.05), but no significant in moisture freshener group (P=0.915).The skin hydrations and water-holding capacity correlated well with each other (r=0.856, P<0.001), but no correlation between them and TEWL value. The volunteers’self-evaluation shows improvements in skin hydration. The clinical grade evaluated by dermatologist also show improvements. Drying score correlated well with skin hydrations and water-holding capacity (r=-0.177, P<0.05, r=-0.264, P<0.001; respectively). The subjective estimation were paralleled well with the objective measurements. Conclusion:The skin hydration and Water Sorption-desorption test are sensitive methods for evaluating moisturizers efficacy, and correlated well with each other. Water Sorption-desorption test also reflects hydration dynamics of Stratum Corneum. TEWL were not sensitive for skin hydration for normal subjects. The subject’s self-estimation and clinical assessment parallel well with instrumental measurements. Combining them, it’s a more comprehensive approach to the moisturizorefficacy evaluation.