The Effect Of Dexmedetomidine In Neurosurgery Of The Induction Of General Anesthesia On Bispectral Index And Hemodynamic

Objective The aim of the study is to investigate the effect of Dexmedetomidine in the induction of general anesthesia on bispectral index and hemodynamic, in order to provide theoretical foundation for dexmedetomidine in neurosurgery.Method Forty patients (ASAⅠ-Ⅱ) aged 18-60 years old, weighting 40-80kg,undergoing elective neurosurgery were randomly assigned to anesthesia with saline (group N) and anesthesia with dexmedetomidine (group D).The patients were intramuscularly injected with phenobarbital 0.1g and scopolamine 0.3mg before operations. After entering the operating room, the patients were opened peripheral venous channels and monitored Electrocardiogram(ECG), systolic blood pressure(SBP), diastolic blood pressure(DBP),pulse oxygen saturation (SpO2) and Bispectral (BIS). They were randomly allocated to receive dexmedetomidine 0.5μg/kg (Group D) (n=20) or the saline of the same dose (Group N) (n=20), then the two groups were both induced with midazolam. When BIS reduced to 60, we injected sufentanil 0.3ug/kg and vecuronium 0.1mg/kg.3 minutes later we operated tracheal intubation. HR,SBP,DBP and BIS were recorded at intervals before anesthetic induction (To),5 minutes (T1) and 10 minutes (T2) after anesthetic induction, tracheal intubation (T3),1 minute (T4),2minutes (T5) and 5minutes (T6) after tracheal intubation and we also recorded the dosage of midazolam.Results There was no significant difference between the two groups before anesthesia induction. BIS of group D was lower than Group N at time T1 and T2 (P<0.05).The dosage of midazolam.for anesthetic induction of group D was lower than group N (P<0.05). Compared with group N, HR and SBP of Group D decreased significantly at time T4 and T5 (P<0.05).HR of T5 and SBP of T5 and T6 in Group D was decreased significantly than To (P<0.05).HR of T5 and SBP of T5 and T6 in Group N was decreased significantly than To (P<0.05)Conclusion Dexmedetomidine (0.5μg/kg) can significantly reduce the BIS value. The hemodynamic is more stable used for induction of general anesthesia than midazolam in neurosurgical patients.