Clinical Analysis On Seizures In Cerebral Venous Sinus Thrombosis

Aim:The aim of this study is to make clinical analysis on seizures followed cerebral venous sinus thrombosis.and to search for the risk factors of seizures in CVST.Method:74patients whose main diagnosis is Cerebral venous sinus thrombosis in our hospital are divided into seizure group(20cases) and non-seizures(54cases).SPSS19is used to compare data by t-test,crosstab,Logistic regression. And make a retrospective clinical analysis on the morbidity,presentations,AED choices.Result:27%(20/74) patients with CVST experiences seizures,50%of them are early seizures(within7days after onset),70%occurred within the2weeks after onset.45%of them were recurrent. Supratentorial lesions(P=0.002),mental status impairment(P=0.014) are the independent risk factors for seizures in CVST in logistic-regression analysis,there were no significant differences between different lobes.CVST patients with focal motor (P=0.002) or sensory (P=0.005) defects, superior sagittal occlusion (P=0.009) are more inclined to had seizures.Intracranial pressure(P=0.77) and D-dimmer(P=0.18) have no siginificant differences between the two groups.In the20patients with seizures, Seiures were generalized in15(75%) patients.focal in3(10%) patients.2(15%) patients presented with convulsive status epilepticus.About AED,6patients took Soudium Valproate.2of them recurred;7patients took Carbamazepine or Oxcarpazepine.no one recurred;3patients took Levetiracetam.l of them recurred.6of74patients(8.1%)given up treatment because of critical illness.4of them had seizures.3were early seizures.About12.5%CVST patients had Hyperhomocysteinemia.none of them had seizures.Conclusion:supratentorial parenchymal lesions, mental status impairment are the independent risk factors of zeizures in CVST, there were no siginificant differences between different lobes, patients with focal motor or sensory defects and superior sagittal occlusion have higher risk of seizures. Carbamazepine or Oxcarbamazepine may be a good AED choice.