Observe The Naoxinkang Ⅱ (NXK Ⅱ) Effect On Myocardial Ischemia With Myocardial Injury Markers And Cardiac Function

Objective: To observe Impact of Nao Xin Kang II (NXKIl) large, medium,small doseson pituitrin (PIT) due to acute myocardial ischemia in rat serum troponin I (cTnI),myoglobin (Mb), and cardiac function in left ventricular shoot The impact of ejectionfraction (LVEF), fractional shortening (FS), left ventricular diastolic diameter (LVDD) at theend, left ventricular end systolic diameter (LVDS), and further explore its mechanism, toprovide experimental basis for the use of Chinese medicine clinical on myocardial protection.Method:8-10weeks of healthy Wistar rats of clean grade,60were randomly divided into sixgroups: blank control group, negative control group, positive control group, NXKIl, large,medium and small dose group. Rats in each group in the same living environment, a unifiedfeeding solid animal feed, all groups were given liquid gavage for20days except the blankgroup, Rats were injected twice Pituitrin (PIT) Interval of24hours, Preparation acute ratmodel of myocardial ischemia. after the second injection of Pituitrin30minutes, Inspection theECG of rats who were Intraperitoneal injected with1.5%sodium pentobarbital (30mg/kg),after theanesthesia success of,detect the rats Echocardiography On the ECG results in line withsuccessful modeling standards,, measuring left ventricular ejection fraction (LVEF), cardiacfunction, fractional shortening (FS), left ventricular end diastolic diameter (LVDD), leftventricular end-systolic diameter (LVDS). After the second injection of Pituitrin three hours,Blood to detect serum troponin I (cTnI), myoglobin (MB) content, For acute myocardial ischemia ratscaused by Pituitrin (PIT), The cTnI, Mb increased range of NXKIl the large,middle dose group weresignificantly lower than the negative control group, Four measurements results of heart functionwere significantly better than the negative control group,the difference has statisticallymeaning (P <0.05), high-dose group was significantly different (P <0.01), low-dose group,the effect has not significant (P>0.05). Conclusion: NXKIl on myocardial protective effectand its mechanism may be associated with increased coronary blood flow, improvemyocardial oxygen supply, promote blood circulation, protect the vascular intima, reduceplatelet aggregation, improve the myocardial enzyme activity, reduction of myocardial cellinjury by hypoxia and enhanced cardiac function.