Correlation Of Plasma Brain Natriuretic Peptide With Parameters Of Heart Function In Hypertenslves

Objective:To explore the variance of indices according varying blood pressure and heart function bydetecting plasma concentration of B-type natriuretic peptide(BNP),echocardiographic heartfunctional parameters and P—wave terminal force in essential hypertensives(EH).To investigatethe correlation of plasma BNP level with echocardiographic heart functional parameters andP—wave terminal force—V1(PtfV1) in patients with EH.Method:83 patients with EH in hospital and outpatient service were divided into two groups:EHwithout heart failure (HF)group (n=46) and EH with HF group (n=37). EH without HF groupwere divided into three sub-groups: grade 1 hypertensives group(n=10), grade 2 hypertensivesgroup(n=17), grade 3 hypertensives group(n=19). EH with HF group were divided into twosub-groups: diastolic heart failure(DHF) group (n=21),systolic heart failure(SHF) group(n=16)．Control group(n=20). Plasma BNP level were determined,LVEF,LVEDD,LAD wereexamined by echocardiography,and Ptf V1 were measured by electrocardiogram inabove-mentioned groups,statistical analysis was applied for the data.Results:(1)The plasma BNP levels in patients with EH(251.7±281.0 pg/ml)were higher than thosein control group(14.5±10.9 pg/ml,P＜0.01). The plasma BNP levels in EH without HF group(36.0±20.1 pg/ml)were higher than those in control group(14.5±10.9 pg/ml,P＜0.01). Theplasma BNP levels in EH with HF group(519.9±214.3pg/ml)were higher than those in EHwithout HF group(36.0±20.1pg/ml P＜0.01)and control group(14.5±10.9 pg/ml,P＜0.01).(2) In EH without HF sub-group, the plasma BNP levels in grade 3 hypertensivessub-group ( 49.0±21.4pg/ml ) were higher than those in grade 1 hypertensives sub-group(24.5±14.1p g/ml,P＜0.05),grade 2 hypertensives sub-group(28.2±12.6pg/ml,P＜0.05)and control group ( 14.5±10.9 pg/ml,P＜0.05 ) , grade 2 hypertensives sub-group(28.2±12.6pg/ml)were higher than those in control group(14.5±10.9 pg/ml,P＜0.05).Butas to plasma BNP levels , there were not significant differences comparing grade 1hypertensives sub-group with control group, grade 1 hypertensives group and grade 2hypertensives group ( P＞0.05). With the elevating of hypertension degree the plasma BNPlevel , LVEDD and LAD were increased , but LVEF and PtfV1 were decreased .(3) In EH with HF sub-group, the plasma BNP levels in EH with SHF(685.6±199.6 pg/ml)were higher than those in EH with DHF group(393.7±118.6 pg/ml,P＜0.05), controlgroup(14.5±10.9 pg/ml,P＜0.05), EH without HF group(36.0±20.1pg/ml P＜0.05), threeEH sub-groups without HF ( 24.5±14.1pg/ml,P＜0.05；28.2±12.6pg/ml,P＜0.05；49.0±21.4pg/ml,P＜0.05).The plasma BNP levels in EH with DHF group(393.7±118.6 pg/ml)were higher than those in control group(14.5±10.9 pg/ml,P＜0.05), EH without HF group(36.0±20.1pg/ml P＜0.05), three EH sub-groups without HF(24.5±14.1pg/ml,P＜0.05；28.2±12.6pg/ml,P＜0.05；49.0±21.4pg/ml,P＜0.05). LVEF,LVEDD,LAD and PtfV1 inEH with SHF group , there were significant differences comparing with DHF group, three EHsub-groups without HF, control group(P＜0.05). With the worsening of HF ,the plasma BNPlevels,LVEDD and LAD were increased,but LVEF and PtfV1 were decreased .(4)The plasma BNP level were negatively correlated with LVEF(r=- 0.826,P＜0．01), butpositively correlated with LVEDD(r=0．829,P＜0．01).The plasma BNP levels were positivelycorrelated with LAD(r=0．784,P＜0．01),but negatively correlated with PtfV1(r=-0．754,P＜0．01)．Conclusions:Meanwhile the plasma BNP level,echocardiographic heart functional parameters and Ptf V1are detected,it will be obtained that heart damage degree, exact diagnosis of DHF andcomprehensive assessment of left heart function in hypertensives．...