Chemical Constituents Of Buddleja Davidii Hemsl

Buddleja davidii is from Buddleja family. It is a kind of fast growing deciduous shrub. It originated in the central and south-western China and then came to New Zealand, Europe, Australia, Canada and the United States. Now it is distributed in China except the northeast region of China. The genus has a high ornamental value, and many foreign countries have developed it into commercial products of which " Buddleja davidii with Blue leaves "," Buddleja davidii with White leaves" and other nice varieties have been introduced into China’s cultivation. In addition, the Buddleja plants also have a strong physiological activity. As early as in the Southern Song Dynasty, China had medicinal recorded on its flowers, leaves, bark, roots and fruit. It’s spicy and slightly bitter, toxic, and it can expel wind and cold, promote blood circulation and relief pain. It also has the effect of the insecticide detoxification. In folk medicine remedies, it is used for the treatment of stroke, headache, neurological disorders, conjunctival congestion, clustered nebulae, removal of heat, replenishment of the liver, and clearing the corneal opacity. Phytochemical studies on Buddleja species have led to the isolation of flavonoids, triterpenoids, phenylethanoids, saponins, and andseveral phenylethanoid glycosides. However, there is no previous work reported on the chemical constituents of Buddleja davidii. In this thesis, we will report the systematic studies on chemical constituents.14known compounds which were isolated from the whole herb of Buddleja davidii belong to the flavonoids(1-7), phenylethanoid glycosides(8-11) and sterides(12-14), by means of crystallization, recrystalization, polyamide column and silicagel column chromatography. Their chemical structures were elucidated on the basis of physicochemical properties and spectroscopic methods including MS、1H-NMR,13C-NMR and DEPT. These compounds are Apigenin(1), Apigenin-7-O-β-D-glucoside(2), Acacetin(3), Acacetin-7-O-β-D)-glucoside(4), Acacetin-7-O-α-L-rhamnopyranosyl-(1-6)-β-D-glucopyranosde (5),luteolin(6),luteolin-7--β-D-glucoside(7),CraniosideA(8),EutigosideA(9),1-O-4-dimethoxyph-enylethyl-4-O-3,4-dimethoxyphenylethy-β-D-glucopyranose(10),Isomartynoside(11), Stigmaster-ol glucoside(12),β-sitosterol(13) and daucosterol(14). All these compounds were obtained from Buddleja davidii for the first time and compound10and11were obtained from the genus Buddleja for the first time. These findings can provide a chemical basis for the development and utilization of the plant resources, as well as to study its biological activity.