Clinical Study Of Huoxue Therapy For The Treatment Of Acute Exacerbation Of Chronic Obstructive Pulmonarv Disease (COPD)with Type â…¡ Respiratory Failure

ObjectiveTo investigate the prevalence feature and therapeutic measure of AECOPD in Kashi, Xinjiang district and try to find out the strategy to control and prevent the occurrence of COPD in that area. Besides, Huoxue therapy was applied in AECOPD with type Ⅱ respiratory failure patients. Blood gas, blood viscosity and combined symptom etc. were analyzed and compared with control group to evaluate the clinical efficiency of Huoxue therapy.MethodsDuring February2011to November2011,97acute exacerbation of chronic obstructive pulmonarv disease (AECOPD) subjects in Kashi district, Xijiang province were investigated. The age, gender and nationarity distribution of patients as well as its medication therapeutic methods were summarized to investigate the prevalence characteristic and therapeutic strategy of AECOPD in that district. Furthermore, according to random single blind control principle, all the subjects were categorized into DanHong injection therapy group, noninvasive ventilation and western medication therapy control group. The patients of these three groups were treated with Danhong injection, noninvasive ventilation and standard western medication respectively.Blood pH, arterial partial pressure of carbon dioxide (PaCO2), arterial partial pressure of oxygen (PaO2), white blood cell(WBC)、NE%、red blood cell(RBC)、 HCT, etc were analyzed. The patient’s symptoms, such as coughing, sputum and panting, etc were graded using APACHEⅢ system up to evaluate the clinical efficiency of Danhong injection. All data was analyzed with SPSS. P=0.05was used as test level. ResultIn Kashi district, Xinjiang province, COPD prevalence is increasing with age and maximal prevalence rate appears in70-79years old population. Only a few people in80-89years old suffer from COPD. These results indicate that most of the patients died before80years old because of COPD, which possibly is one of the major causes of death of elders in kashi district. Furthermore, the male COPD prevalence is significantly higher than female and uyghur nationality patients account for the large COPD proportion. About20%COPD patients were diagnosed tuberculosis. In Kashi renmin hospital, the major therapeutic strategy of AECOPD includes anti-inflammmation, bronchial dilation and sputum dilution。51%AECOPD patients were treated with Huoxue therapy(Danhong injection). The result showed that all the laboratory parameters of Danhong injection therapy group were ameliorated compared with non-Danhong injection control group (P<0.05).In terms of liver function, kidney function and blood glucose, there were no statistic significant difference before and after treatment both in DongHong injection group and other therapeutic group (P>0.05). There were no adverse effect reported by patients who received Danhong injection treatment.ConclusionGender,age, nationality, living habit and tuberculosis are relative with the prevalence of COPD in Kashi district. To prevent and control COPD, patient’s education should be carried out to change their living style and reduce their exposure frequency to COPD risk factors.Danhong injection is able to improve the respiration, coughing and sputum secretion and other symptom of AECOPD patients with good safety and efficiency.