Takes Red Pill Shui Jianye For A Long Time To The Big Mouse Heart Function And The Heart Tectology Influence

【Objective】This topic plans from the animal experimentation to begin, launches the red pill long-termtoxicity thoroughly to the heart function and the heart tectology influence research, in order toenhances the red pill the medication safety coefficient, thus the medicine present’s clinicalsecurity will take for this reason provides the scientific experiment data.【Methods】Takes Wistar big mouse80, divides into the red pill high, middle and low monitoring teamand the normal control group4groups stochastically, each group of each20, are half and halffemale and male, divides the cage to feed. Presses33g,16.5g, the5.5g crude drugs in turnrespectively for the medicine group/(kg d) the dosage fills the stomach; The control group fillsthe stomach with the distilled water, fills the stomach volume fills when the stomach for thehigh monitoring team big mouse to need the solution for the same level body weight conditionunder the dosage, fixed time fills the stomach every day1time, each group fills the stomach90days continuously, after stopping the medicine, continues to observe for3weeks.【Results】Weight: The experimental result showed: Before for medicine, each group of big mousebody weight not remarkable difference (P﹥0.05); Compare for the medicine time and thecontrol group, the red pill high monitoring team big mouse body weight obviously drops (P﹤0.05), in red pill, low monitoring team big mouse body weight not remarkable difference (P﹥0.05). Explained that the red pill high monitoring team affects the big mouse body weight thegrowth, the red pill low monitoring team affects not obviously to the big mouse body weight.The recovery period each group of big mouse body weight compares not remarkable difference(P﹥0.05).Heart rat Electrocardiogram: Compare for the medicine time and the control group,thered pill high、 middle、 low dose team Heart rat no significant difference (P>0.05).；Compare for the medicine time and the control group,the red pill high、 middle、 low doseteam Electrocardiogram no significant difference.； Recovery period the rats Heart ratElectrocardiogram no significant difference (P>0.05). Heart function tests: Compare for the medicine time and the control group,the red pillhigh、 middle、 low dose team LDH、CK no significant difference (P>0.05).；Explained thatthe red pill high、 middle、 low dose team may not cause the big mouse heart cell damage。Recovery period the rats LDH、CK no significant difference (P>0.05).Hemoglobin、red blood cells and PLT tests:Experimental drugs on rats in each group theimpact of hemoglobin levels was not significant (P>0.05); Experimental drugs on the valuesof red blood cells of rats caused no significant effect (P>0.05); Experimental drugs on thevalues of PLT of rats caused no significant effect (P>0.05).Heart morphology:both administration and recovery of the heart of rats did not causeabnormal tissue morphology effects.Recovery to observe:there is no delayed heart toxicity.【Conclusion】1Take large doses of pill can affect the body weight, body weight showed slow growth, butcan be restored after treatment.2Long-term used red pill in heart rate and an electrocardiogram no significant difference.3Long-term used red pill on rats in each group the impact of hemoglobin levels、the valuesof red blood cells of rats and on the values of PLT of rats were not significant difference.4Long-term use red pill on heart function and tissue morphology no significant difference.5Red Pill on rat heart，there is no delayed heart toxicity.