Clinical Study On Jiawei Qihuangyin Therapy On ACR In Diabetic Kidney Disease

Backgroud:Diabetic Kidney Disease is one of the microvascular complications of diabetic, can be expressed as proteinuria, hypertension, renal injury and so on, and it is the1cause of End Stage Renal Disease. The pathogenesis of DKD complicated, early lack of obvious clinical manifestation. Once the DKD patients developed into clinical proteinuria, then his renal function will progressive deterioration. Microalbuminuria is a main mark of the impaired glomerular endothelial function, and it is the renal system change in the early indications. In clinical work, scholars found that the main type of syndrome in patients with early DKD is Qi-Yin deficiency and blood-stasis syndrome.Objective:To discuss the clinical sffects of therapy of Jiawei Qihuangyin in early Diabetic Kidney Disease of deficiency of both Qi and Yin with Blood stasis and the changing level of the mALB/CR before and after treatment.Methods:A randomized controlled study design was used in this research. Sixty patients with III phase DKD of deficiency of both Qi and Yin with Blood stasis syndrome were selected and randomly divided into two groups:treatment group and control group. Patients in control group were received basic treatments including diet control, reduce blood glucose and oral Fosinopril Sodium tablet, l0mg every day lasting eight weeks. Additionally, patients in treatment group oral Jiawei Qihuangyin drink, one dose a day,200ml each time both in the moring and eveing, lasting eight weeks. The changes of clinical symptoms and effect, mALB/CR, fasting blood glucose, glycated hemoglobin(llbAlc), serum creatinine(Scr) were observed before and after treatment.Results:1. In terms of improving clinical symptoms, the overall efficiency was86.7%in the treatment group, and63.33%in the control group, the differences between two groups is statistically significant(P<0.05).The Chinese medicine cl inical symptom scores of each group decreased after treatment, The difference has statiscally significant in each group after treatment(P<0.05). Therapies of treatment group were superior to those of the control group in improving main clinical syptoms.2. In two groups, ACR, FPG, HbAlc were decreased after treatment, and the difference has statiscally significant in each group after treatment (P<0.01). Compared with the control group, the effect of treatment group was superior to the control group, there was statistically significant difference.3. After treatment, BUN, Scr were no significant difference in each group, before and after treatment those difference was no statistically significant(P>0.05). The security indicators such as Liver function has no significant changes before and after treatment. There were no obvious adverse effects during the treatment.Conclusion:After treatment, blood glucose, HbAlc and ACR of two group patients were significantly decreased compared with those before treatment, but the addition of Chinese medicine Jiawei Qihuangyin curative effect of the treatment group is superior to simple western medicine control group.