Researches Of Elderly And Mild To Moderate Hypertension And Abnormal Glucose Metabolism Traditional Chinese Medicine Syndrome Features With IL-6,Tnf-α And Other Indicators

Objective:Exploring the correlation of the old and young to moderate essential Hypertension with abnormal glucose metabolism in patients with TCM syndromes and inflammatory factors Interleukin-6(IL-6) and Tumor necrosis factor-a(TNF-a) and other indexes,in order to improve the understanding of the disease of TCM syndromes and provide a reference for the objective of TCM diagnosis,treatment and prognosis.Methods:Collection of old and young to moderate essential hypertension,abnormal glucose metabolism in patients with Nanjing Chinese medicine hospital inpatients in December2010to February2012met inclusion criteria of60cases,In accordance with the2002new drug treatment of hypertension in the Chinese medicine clinical research guiding principles hypertension TCM standards,Hypertension and abnormal glucose metabolism is divided into:the anger the hyperactivity card,hyperactivity card,phlegm dampness card,yin and yang deficiency.At TCM syndrome score in the standards of TCM clinical designate according to the degree to judge,filling in the survey data table,detecting of biochemical indicators,calculating body mass index and insulin resistance index and taking the test in patients with fasting12hours after the blood5ml for to sent the Laboratory detection of inflammatory cytokines IL-6and TNF-a level. Fiinally,We take the SPSS17.0statistical analysis software to statistical analysis and process on the data collected,and analysis of TCM syndromes and inflammatory factors in the correlation.Results:In the60patients studied,male patient of Hypertension with abnormal glucose metabolism visits a higher proportion and more common in autumn and winter attenders.The yin permit a higher proportion of TCM syndrome distribution. Blood stasis, phlegm and folders of evidence in clinical practice are very common.The certificate type no significant difference in gender distribution.Clinical impaired fasting glucose group common to phlegm dampness card group with diabetes is common deficiency of both yin and yang.Hyperactivity syndrome diastolic blood pressure and total cholesterol level are higher than the other syndromes.Phlegm dampness syndrome body mass index (BMI),fasting insulin,insulin resistance index, interleukin-6and tumor necrosis factor-a levels are higher than the other three syndrome types.The yin and yang deficiency patients fasting plasma glucose and postprandial blood glucose is higher than the other syndromes.Hyperactivity syndrome of low-density lipoprotein cholesterol and apolipoprotein B levels are higher than the phlegm dampness card.The classification of blood pressure level have a certain relevance of duration of disease,dietary habits,etc.Blood pressure level of risk associated with smoking,postprandial blood glucose and apolipoprotein B.Interleukin-6levels of some associated factors are the high-sensitivity C-reactive protein,homocysteine,dietary habits,alcohol consumption and levels of uric acid.Elevated tumor necrosis factor-a levels in some associated factors include a family history of hypertension.Conclusion: This topic preliminary observations that the inflammatory response involved in the process of old and young to moderate essential Hypertension merger abnormal incidence of glucose metabolism.There are some differences in inflammatory cytokines and some basic indicators of the metabolic indicators of the Chinese medicine each card type.It will be help to provide some objective basis for the clinical syndrome type.