Application Of Wave Intensity And Echo-tracking Technique In Evaluating Hemodynamics Of Coronary Heart Disease

Objectives: To evaluate the hemodynamics of coronary heart disease (CAD) patientsusing Wave intensity (WI) and Echo-tracking (ET) technique, finding out andresearching the changes of cardiac and arterial functions in coronary heart diseasepatients with different severity of coronary stenosis and acute myocardial infarction(AMI) patients, analyse the correlations between the parameters of the cardiac andarterial functions. Explore clinical meaning and usefulness of noninvasive WI and ETtechnique and provide reliable objective evidences for clinical diagnosis and treatmentof cardiovascular diseases.Subjects and Methods:Subjects: Coronary heart disease patients hospitalized in our department from June,2011to October,2011,all were diagnosed by Coronary angiography (CAG).①CADstudy:101patients classified into three groups according to severity of coronary stenosisby CAG, group A with one branch stenosis, group B with two branches, group C withthree branches or left main coronary artery (LM),②AMI study:59patients classifiedinto two groups, D was stable angina pectoris (SAP) group, E was AMI group. Controlgroup was composed of healthy people matched with study groups by age and sex in thesame period.Methods: WI and ET examination were performed in all subjects by ALOKAα-10colorDoppler ultrasonic diagnostic apparatus, main paremeters including stiffness parameter(β), elasticity modulus (Ep), pulse wave velocityβ (PWVβ), artery compliance (AC),augmentation index (AI), negative area (NA), W1, W2. Parameters of these groups weremade comparison and linear correlation analysis when integrated with common data andechocardiography examination.Results:①CAD study: The carotid artery intima media thickness (C-IMT)increased in three groups and paralleled with the severity of coronary stenosis, pulse pressure(PP)increased in group B compared with normal（P＜0.01) and group C（P＜0.05), Epincreased in all three groups（P＜0.05), AC decreased in group C comparing group Aand normal (P＜0.05), AI became higher in group B than other groups, W1in B groupdecreased compared with normal (P＜0.05), W1and W2in C group decreasedcompared with group Aand normal (P＜0.05).②AMI study: Severity of coronary stenosis was higher in group E than group Daccording to CAG analysis (P＜0.01), C-IMT in group E increased (P＜0.01), Ep,PWVβ, AI increased in group D (P＜0.05) compared with normal, W1decreased ingroup E compared with group D and normal (P＜0.05), W2and NAdecreased in groupE compared with group D (P＜0.05).③Correlation analysis: W1has significant positive relationship with W2, β, Ep andPWVβ (P＜0.01)while having negative relationship with AI (P＜0.05); W2correlatedpositively with NA, PP (P＜0.01); NA and β also have positive relationship with PP (P＜0.01).Conclusions: WI and ET are noninvasive and feasible new ultrasonic techniques whichcan effectively and sensitively evaluate hemodynamics changes and overall function ofcardiovascular system in Coronary heart disease patients, which has clinical applicationvalue.