Expression Of Foxp3and Pcdgf Expression In Squamous Cell Carcinoma And Precancerous Lesions

Objective：To investigate the expression in the tissues and the clinicalsignificance of Foxp3and PCDGF in normal skin, actinic keratosis andcutaneous squamous cell carcinoma.Methods: Immunohistochemical staining was applied to detect theexpression of Foxp3and PCDGF in tissue samples of15cases of actinickeratosis,28cases of Bowen’s disease,26cases of cutaneous squamouscell carcinoma, and8cases of normal epidermal tissue.Results: Foxp3and PCDGF were both expressed in epidermisneoplasms and precancerous lesions but not in the normal epidermal tissue.There was no significant difference of Foxp3expression between the SCCand BD samples (P>0.05), while in the samples of AK, Foxp3expressionwas significantly lower than that in BD and SCC samples (P<0.05). Foxp3+regulatory T cells were found among the tumor infiltrating lymphocytes.The positive expression rate of PCDGF was gradually increased in AK、BDand SCC. Foxp3and PCDGF expression in squamous cell carcinoma andprecancerous lesions not found a clear correlation.Conclusion: The abnormal expression of Foxp3and PCDGF playedan important role in the occurrence and development of squamous cellcarcinoma of the skin epidermis, may be associated with the developmentof cutaneous squamous cell carcinoma and invasive growth.