The Clinical Significance Of PLGF And Hs-CRP In The AMI Of Elderly

obejects: To explore the changes of placenta growth factor(PLGF) andhing-sensitivity c-reactive protein(hs-CRP) and their clinical significance in old agedpatients with acute myocardial infarction (AMI).methods:80Patients with Time Selecting Operation of PCI with acute myocardialinfarction(AMI) were divived into two groups according to their age:old-aged groupand none old-aged group.40health people were recruited group as control. Allresearch objects were respectively extracted Cubits venous blood with4ml in24hours,3days and7days. PLGF and hs-CRP were determined by ELISA method(enzyme-linked immuneosorbent assay, ELISA). All subjects were examinated bycoronary angiography after7days.Major adverse cardiac events(MACE) wereaccouted in the following three months.results:1. The serum concentrations of PLGF of old-aged group with the24hour,thethird day,the7th Day were respectively(24.13±6.78）pg/mL、（32.19±8.35）pg/mL、（21.04±5.22）pg/mL. At the same point,the serum concentrations of PLGF of noneold-aged group were respectively（15.03±3.81）pg/mL、（20.08±4.12）pg/mL、（15.42±3.26）pg/mL. Two groups were higher than the control group whose serumconcentrations of PLGF the same time point were respectively（8.23±1.37）pg/mL、（8.86±1.86）pg/mL、（8.68±1.19）pg/mL，and the change had statistically significant(P <0.05). At the same time,the serum concentrations of PLGF of the elderly group(>65years old) were higher than those of none elderly group (≤65years old)(elderlygroup VS none elderly group, P <0.05)and it was also statistically significant.2. At the same time points, the serum concentrations of hs-CRP of the elderly group (>65years old) were respectively （27.38±6.95）mg/L、（31.5±7.31）mg/L、（13.3±3.83）mg/L,and those of the none elderly group (≤65years old) wererespectively25.15±5.73）mg/L、（29.78±6.71）mg/L、（12.38±4.25）mg/L.These twogroups had no obvious difference (P>0.05),so this difference had no statisticallysignificance. But,the serum concentrations of hs-CRP of the two groups were higherthan the control group whose serum concentrations of hs-CRP were respectively（4.08±1.05）mg/L、（5.29±1.51）mg/L、（5.08±1.23）mg/L，(P <0.05)and thedifferences had statistically significant.3. After three months,the happening rates of the major cardiovascular adverseevents (MACE) of the old-aged group were higher than those of the none old-agedgroup (23.81%VS7.89%， P＜0.05）, and the difference was statisticallysignificant.The happening rates of the cardiovascular adverse events (MACE) of thegroup with high level of PLGF were higher than those of the group with low level ofPLGF.conclusion:1. The serum concentrations of PLGF of old-aged patients with AMI arehigher.While the level of hs-CRP of the two groups has no obvious difference.2. The emerge and increasing happening rates of major adverse cardiacevents(MACE) may be connected with PLGF in elderly people with acute myocardialinfarction (AMI)after three months.But it may have nothing to do with thehigh-sensitivity c-reactive protein (hs-CRP).