The System Evaluation Of Tonify Deficiency And Activation Blood Mainly To Treatment Of Arrhythmia

Objective To evaluate the therapeutic effects and safety of the method of tonify deficiency and activation blood in treatment with arrhythmia by the method of evidence-based medicine system.Methods Based on a comprehensive collection (1989-2012) CBM, CNKI, VIP and wanfang data and the database tonify deficiency and activation blood as the method of treatment arrhythmia randomized controlled clinical study of literature with Meta-analysis method to get statistical data, the system evaluate the efficacy and safety by using RevMan4.2software.Results43RCTs totally4598cases were included, with all trials of low methodological quality without5trails.Statistical analysis results are shown:all trials adopted blinding method and allocation concealment.Only6trials introduces random method, but without1trail specific randomized measures, the other11trials just has the word of "random", without the random method.There are3trials which mentioned the follow-up and the time limit.Only19trials have the description of adverse reaction.There are42trials recognized by domestic diagnostic criteria.Only22trials have mentioned the into and exclusion standard.Meta-analysis results of the treatment of arrhythmia mainly using tonify deficiency and activation blood shown thatin the comparison with control group, the effective rate of the synthetical effect has statistical significance OR=2.12,95%的CI为(1.46,3.10), which means that the effective rate of the synthetical effect of the treatment of arrhythmia mainly using tonify deficiency and activation blood was superior to the control group;The significant effective rate also has statistical significance OR=1.54,95%的CI为(1.19,2.03), which means that the significant effective rate of the synthetical effect of the treatment of arrhythmia mainly using tonify deficiency and activation blood was superior to the control group.In the comparison with control group, the effective rate of the electrocardiogram (ECG) effect has statistical significance OR=1.97,95%的CI为(1.39,2.79),which means that the effective rate of the synthetical effect of the treatment of arrhythmia mainly using tonify deficiency and activation blood was superior to the control group;The significant effective rate also has statistical significance OR=1.44,95%的CI为(1.21,1.70), which means that the significant rate of the ECG effect of the treatment of arrhythmia mainly using tonify deficiency and activation blood was superior to the control group.In the comparison with control group, the effective rate of the symptom effect has statistical significance OR=3.67,95%的CI为(2.93,4.59), which means that the effective rate of the synthetical effect of the treatment of arrhythmia mainly using tonify deficiency and activation blood was superior to the control group;The significant effective rate also has statistical significance OR=2.08,95%的CI为(1.46,2.97), which means that the significant rate of the symptom effect of the treatment of arrhythmia mainly using tonify deficiency and activation blood was superior to the control group.In the comparison with control group, after treatment,the number of abnormal arrhythmia of24h hotel has statistical significance WMD=-127.52,95%的CI为(-205.99,-49.05), which means that the number of abnormal arrhythmia of24h hotel of the treatment of arrhythmia mainly using tonify deficiency and activation blood was inferior to the control group.In the comparison with control group, after treatment,the content of cholesterol has statistical significance WMD=-0.68,95%的CI为(-1.06,-0.30), which means that the content of cholesterol of the treatment of arrhythmia mainly using tonify deficiency and activation blood was inferior to the control group; In the comparison with control group, after treatment,the content of triglyceride has statistical significance WMD=-0.24,95%的CI为(-0.47,-0.00), which means that the content of triglyceride of the treatment of arrhythmia mainly using tonify deficiency and activation blood has no significant difference with the control group; In the comparison with control group, after treatment,the content of low density lipoprotein has statistical significance WMD=-0.54,95%的CI为(-0.71,-0.37), which means that the content of low density lipoprotein of the treatment of arrhythmia mainly using tonify deficiency and activation blood was inferior to the control group; In the comparison with control group, after treatment,the content of high density lipoprotein has statistical significance WMD=-0.24,95%的CI为(-0.47,0.00), which means that the content of high density lipoprotein of the treatment of arrhythmia mainly using tonify deficiency and activation blood has no significant difference with the control group;In the comparison with control group, the incidence of adverse reactions rate has statistical significance OR=0.24,95%的CI为(0.16,037), which means that the effective rate of the recurrence rate of the treatment of arrhythmia mainly using tonify deficiency and activation blood was inferior to the control group.The pour funnel figure of the effective rate of the synthetical effect and the significant effective rate of symptom effect have equal distribution which means that the bias is less likely to occur.The pour funnel figure of other indicators have unequal distribution which means that the bias is likely to occur.Conclusion The effective and significant effective rate of the synthetical, ECG, symptom effect of the treatment of arrhythmia mainly using soothing tonify deficiency and activation blood was superior to the control group;And also has the merit of good safety and low the recurrence rate.