Quyidifang On Insulin Resistance In Type2Diabetes Mellitus Patients With Serum Ppar Gamma Effects In Clinical Research

Objective:Through the observation of quyidifang which by supplementing qi and nourishing Yin, activating blood and expelling phlegm method for composing principle, combined with metformin hydrochloride tablets for the yin deficiency of both qi and blood stasis phlegm obstruction type insulin resistance in T2DM patients with syndrome of traditional chinese medicine related and serum PPAR gamma, FFA, insulin resistance index (HOMA-IR) test indexes effect, discuss combination of Chinese and Western medicine in treatment of yin deficiency of both qi and blood stasis phlegm obstruction type insulin resistance in T2DM effect.Method:60patients with the yin deficiency of both qi and blood stasis phlegm obstruction type insulin resistance in T2DM patients were randomly divided into a treatment group and a control group. Two groups of patients were given the same foundation treatment under the premise, treatment group was given quyidifang decoction of traditional chinese medicine, a dose of daily water to cook two taking medicine juice300ml, daily morning and evening each serving a150ml, and combined with metformin hydrochloride tablets500mg, orally three times daily; the control group was given500mg of metformin hydrochloride tablets, orally three times daily. The course of treatment was8weeks. To observe two groups of patients before and after treatment:serum levels of peroxisome proliferator activated receptor gamma (PPAR gamma), HOMA-IR, FFA, FPG,2hPG, FINS and traditional chinese medicine syndrome integral change.Result:1. After eight weeks of treatment, two groups of patients with PPAR gamma were significantly decreased (P<0.01), and the treatment group PPAR gamma than the control group decreased significantly (P<0.01).2. After eight weeks of treatment, two groups of patients with HOMA-IR were significantly decreased (P<0.01), and the treatment group compared with the control group, HOMA-IR decreased significantly (P<0.01).3. After eight weeks of treatment, two groups of patients with FFA, FPG,2hPG, FINS were significantly decreased (P<0.01).Among them, the treatment group compared with the control group, the FFA,2hPG decreased significantly (P<0.05), the treatment group compared with the control group, the FPG were not different (P>0.05), the treatment group compared with the control group, the FINS decreased significantly (P<0.01).4. After eight weeks of treatment, two groups of patients with traditional chinese medicine syndrome integral than before treatment were significantly decreased (P<0.01), the treatment group of traditional chinese medicine syndrome integral than the control group decreased significantly (P<0.01).Conclusion:1. Quyidifang can reduce the yin deficiency of both qi and blood stasis phlegm obstruction type insulin resistance in T2DM patients with HOMA-IR, improve insulin resistance.2. Quyidifang can increase the yin deficiency of both qi and blood stasis phlegm obstruction type insulin resistance in T2DM patients with serum PPAR gamma level, which may be one of the mechanisms of improving insulin resistance.3. Quyidifang can reduce the yin deficiency of both qi and blood stasis phlegm obstruction type insulin resistance in T2DM patients withFFA,2hPG,FINS.4. Quyidifang can reduce the yin deficiency of both qi and blood stasis phlegm obstruction type insulin resistance in T2DM patients with traditional chinese medicine syndrome integral,improve clinical syndromes of traditional Chinese medicine.