Analysis Of Pathogenic Bacteria Culture And Sensitivity For Infected Children With Congenital Heart Disease

Objective： To identify the distribution and drug resistance ofcommon and special pathogens in the infected patients with congenitalheart disease for providing evidence of clinical anti-infection therapy.Methods： To retroactively analyse the results of302case ofinfected children with congenital heart disease in our department ofpaediatrics. And to retroactively analyse the results of pathogenicbacteria culture and susceptibolity of these case.Results：302cases of infected children with congenital heartdisease，of which1years old baby accounted for66.89%.The top fivecongenital heart diseases were VSD (31.79%)、ASDandVSD(20.86%)、TOF (10.60%)、 ASD(9.27%)、 PDA(7.26%). According tohemodynamics,left to shunt congenital heart diseases weremajor,accounting for75.14%. The top detection rate of pathogenculture was Central venous catheter tip culture,84.44%, followed by the endotracheal tube tip culture, culture of the sputum, blood cultures,respectively73.81%,33.52%,12.68%(P<0.05);Form thepatients’phlegm， blood， and secretion， we had separated190pathogens，and among which there were116Gram-negative bacteria，accounting for63.16%of total；63Gram-positive bacteria，33.16%ofthe total；and7fungi，3.68%.In179sputum specimens，60sputumcultures were positive，and the positive rate was33.52%；In213bloodspecimens，26blood cultures were positive，and the positive rate was12.21%；In84tracheal secretion specimens，62secretion cultures werepositive，and the positive rate was73.81%；In45central enous catheterspecimens，38cultures were positive，and the positive rate was34.44%；20pathogens were proven.The top five Gram-negative strains wereEscherichia coli（Eco），Klebsiella pneumonia（Kpn），Pseudomonasaeruginosa（Pae），Bowman’s acinetobacter（Aba），Stenotrophomonasmaltophilia（Pma）；The top three Gram-positive strains were Coagulasenegative staphylococci（Scn）（Sau），Enterococcus caecalis（Accc）；Most bacteria were responsive to Linezolid，Rifampicin，Gentamycin，Teicoplanin，Chloramphenicol，Ciprofloxacin，Levofloxacin，；And mostbacteria were responsive to Meropenem， Tienam， Levofloxacin，Amikacin， Cefoperazon and Sulbactam， Piperacillin-tazobactam，Cefepime，Ciprofloxacin.Conclusion： In the infected patients with congenital heart disease， gram-negative bacteria were the most common pathogens，combine withgram-positive bacteria. Because of its high rate of antibiotic drugresestance，a wide ariety palthogenic bacereia，cross tesistance tomultiple antibiotic；appropriate etiological culture is very important toreduction bacerial drug resistance and suprinfection produces.We shouldchoose antibiotics which were sensitive to gram-negative bacereiasupplemented by combination therapy with drug sensitive togram-positive bacteria.